| Title: | Whole-milk consumption decreases the risk of inflammatory bowel disease: a two-sample Mendelian randomization analysis |
| Journal: | Journal of Bio-X Research |
| Published: | 25 Mar 2021 |
| DOI: | https://doi.org/10.1097/jbr.0000000000000094 |
Publication 9618
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Abstract
Abstract Objective: The impact of dairy fat on inflammatory bowel disease remained inconclusive. We aimed to compare the effects of whole-milk and skimmed-milk consumption on the risk of inflammatory bowel disease using a Mendelian randomization analysis. Methods: We conducted a genome-wide association study of the preference for whole versus skimmed milk using data for 20,200 whole-milk consumers and 67,847 skimmed-milk consumers from the UK Biobank. The lead single nucleotide polymorphisms in the associated loci were identified at the genome-wide significance level, and were further employed as instrumental variables for whole-milk preference. We conducted a two-sample Mendelian randomization analysis with whole-milk preference as the exposure and inflammatory bowel disease as the outcome. The pleiotropic effects and heterogeneity of the instrumental variables were estimated using Mendelian randomization-Egger regression and Cochran Q test, respectively. This study was conducted using the UKB resources under the application "53536". The UK Biobank was approved by the North West Multi-center Research Ethics Committee, the National Information Governance Board for Health and Social Care in England and Wales, and the Community Health Index Advisory Group in Scotland. Results: The genome-wide association study identified five lead nucleotide polymorphisms associated with whole-milk preference. Mendelian randomization indicated that whole-milk preference significantly decreased the risk of inflammatory bowel disease ( β =−1.735, P = 0.048). Of the two subtypes, whole-milk preference was associated with a lower risk of Crohn disease ( β =−2.549, P = 0.032), but had no significant effect on the risk of ulcerative colitis ( β =−1.002, P = 0.44). Conclusion: Consumption of whole-milk fat may protect against Crohn disease, compared with skimmed milk. This conclusion was based on causal inference in a cohort study, and further validation in randomized controlled trials is warranted. </p>
11 Authors
- Jiuling Li
- Haoxue Zhu
- Aowen Tian
- Ying Guo
- Xiaoxuan Zhao
- Miaoran Zhang
- Lanlan Chen
- Jianping Wen
- Jianli Yang
- Baiyu Qi
- Peng Chen
1 Application
| Application ID | Title |
|---|---|
| 53536 | The roles of diets in disease prevention and treatment and underlying molecular mechanisms |
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