| Title: | Environment factors and genetic risk and its association with metabolic syndrome in the intergenerational transmission |
| Lead Institution: | Chongqing Medical University |
| Principal investigator: |
Application 160957
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About
Metabolic syndrome has been a threat to human health worldwide. It is a complex disorder caused by a combination of genetic and environmental factors, including diet, lifestyle and health care or policy. Genetic factors increase risk of metabolic syndrome, but the extent to which this can be offset by environmental factors remains largely unknown. Therefore, we aim to do a comprehensive 36-month study to investigate whether healthy environmental factors are associated with lower risk of metabolic syndrome regardless of genetic risk. Our study would provide important implications for public policy makers to prevent and treat metabolic syndrome.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 21123 | Accelerated biological aging mediates the associations of plasma lactate and the glucose-lactate index with MASLD: a prospective cohort study | Xuejiao Pu (+7) | 2026 | Clinical Epigenetics |
| 18847 | Association between the atherogenic index of plasma and major adverse cardiovascular events in individuals with metabolic syndrome: findings from the UK biobank | Yuanjia Hu (+7) | 2025 | Cardiovascular Diabetology |
| 17952 | Associations between domestic water hardness and incident type 2 diabetes and the mediating role of metabolomics | Hanwen Zhou (+9) | 2026 | Environmental Pollution |
| 18810 | Associations of macronutrient intake patterns with accelerated biological ageing and life expectancy: evidence from a population-based study in the UK Biobank | Peng Wang (+5) | 2025 | The Journals of Gerontology Series A |
| 20891 | Circulating metabolite signatures mediating the association between minerals in domestic water and incident MASLD: a prospective cohort study | Keyang Li (+9) | 2026 | Frontiers in Nutrition |
Enabling scientific discoveries that improve human health