| Title: | HLA variability and susceptibility to diseases |
| Lead Institution: | HUN-REN BRC Szeged |
| Principal investigator: |
Application 272827
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About
In our upcoming research project, we aim to delve into how variations in Human Leukocyte Antigen (HLA) influence one's susceptibility to various disorders. HLAs play a crucial role in the immune system by helping it recognize foreign molecules. This project seeks to understand whether the specific way these HLA molecules bind peptides (small protein fragments) affects the likelihood of developing certain diseases. Our research will explore several key questions: 1. Does the peptide-binding specificity of HLA molecules determine susceptibility to different disorders? 2. Can we identify clusters of HLA alleles (versions of genes) that have similar peptide-binding properties and are associated with specific diseases? 3. How effective is the knowledge of HLA specificity in predicting disease development compared to just knowing the HLA type? Typically, studies on HLA and disease focus on the differences in HLA alleles. However, many alleles share similar functions in how they bind peptides. By grouping these alleles based on their function rather than just their genetic type, we can improve the power and precision of our analysis. This approach may reveal more connections between HLA types and diseases than previously recognized. To achieve these goals, we will classify HLA alleles into clusters based on how they bind peptides. This classification will be done using cutting-edge techniques in bioinformatics and immunopeptidomics, which study the repertoire of peptides presented by HLA molecules on the cell surface. Once we have identified these clusters, we will use advanced statistical methods and machine learning to examine whether carrying specific HLA variants is linked to higher or lower susceptibility to various diseases. Our ultimate goal is to uncover new biomarkers that could predict an individual's risk of disease based on their HLA characteristics. This research could lead to more personalized approaches in medicine, where treatments and preventive measures are tailored based on an individual's genetic susceptibility to diseases. It opens up possibilities for better understanding immune system functions and their impact on health and disease.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 21080 | HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections | Bettina Magyari (+12) | 2026 | Nature Communications |
Enabling scientific discoveries that improve human health