| Title: | Genome-wide cross-trait analysis for genetic architecture of pan-cancer by UK Biobank |
| Lead Institution: | Nanjing Medical University |
| Principal investigator: | Dr Mulong Du |
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About
Genome-wide association studies (GWAS) have identified multiple risk loci associated with pan-cancer (collectively referred to 33 solid tumors); however, whether these cancers share a common genetic etiology is still not determinate. In this study, we aim to make full use of pan-cancer GWAS databases from UK Biobank to identify more cancer risk-associated susceptibility loci, and explore shared single nucleotide polymorphisms (SNPs) influencing the development of pan-cancer. We will use multiple bioinformatics methods (e.g., partitioned LD score regression (LDSC) analysis, cross-trait meta-analysis, gene-set analysis and expression quantitative trait loci (eQTL) analysis), and a series of biological experiments to explore the roles of shared genetic variants in the development of pan-cancer. Furthermore, we will construct pan-cancer risk prediction model to help identify individuals at high risk of developing cancers. Totally, this research project may help us identify shared genetic variants associated with pan-cancer risk, and make us better understand the molecular mechanisms of cancers development. We may spend about two years to complete this project.7 Publications
Enabling scientific discoveries that improve human health