| Title: | Cross-Omics Studies on Endocrine and Metabolic System Diseases and Multisystem Complications: A Comprehensive Analysis from Mechanism to Clinical Application |
| Lead Institution: | First Hospital of Jilin University |
| Principal investigator: |
Application 511414
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About
1. Background Endocrine and metabolic system diseases, such as diabetes, obesity, hyperlipidemia, hyperuricemia, bone metabolism-related diseases, pituitary diseases, adrenal diseases, thyroid diseases, and parathyroid diseases, not only pose direct health risks to patients, but also frequently lead to cardiovascular diseases , kidney diseases, neurological disorders, and digestive system diseases, causing multisystem complications. These complications significantly increase the complexity of patient management,not only severely impacting patients' quality of life,but also heightening their risk of mortality.Moreover, they present a substantial challenge to global public health. 2. Objectives The primary objective of this study is to elucidate the clinical characteristics and molecular mechanisms of endocrine metabolic diseases and their associated multisystem complications. 3. Study Design and Methods This study is a prospective cohort study utilizing a cohort population from an established database. We screened patients with endocrine and metabolic diseases that met the study criteria, and analyze the data using methods such as Cox regression analysis. 4. Expected Outcomes We expect this study to clarify the clinical associations and pathogenesis of endocrine metabolic diseases and their complications, identify new biomarkers and potential therapeutic targets, and provide more precise diagnostic and therapeutic strategies for clinical practice, thereby improving patient prognosis and quality of life.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20997 | Multidimensional sleep behaviours and incident obesity in postmenopausal women: a prospective cohort study | Ming Zhu (+3) | 2026 | Frontiers in Endocrinology |
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