| Title: | Study on the Correlation Between Multi-System Metabolic Dysregulation Syndrome and Digestive System Cancers in Populations with Different Genetic Risk Profiles |
| Lead Institution: | Chinese Academy of Medical Sciences &Peking Union Medical College |
| Principal investigator: |
Application 534846
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About
Research Question: What types of multi-system metabolic dysregulation are present in populations with digestive system cancers, and what role do genetic factors play in this context? Objectives: This study aims to elucidate the critical role of multi-system metabolic syndrome in the initiation and progression of digestive system cancers, while examining the potential impact of genetic, environmental, and other contributing factors. The ultimate objective is to identify novel biomarkers and therapeutic targets for diagnosis and treatment, reduce cancer incidence and mortality, and facilitate personalized therapeutic approaches. Scientific rationale: Digestive system cancers, such as gastric, colorectal, pancreatic, and liver cancers, have substantial incidence and mortality rates, exerting a considerable social and economic burden on healthcare systems globally. Recent research indicates that multi-system metabolic syndrome-including glucose metabolism dysregulation, lipid metabolism disturbances, amino acid metabolism alterations, and inflammatory responses-often manifests well before the diagnosis of digestive system cancers. These metabolic disruptions are indicative of underlying biological processes involved in cancer development. By examining the relationship between metabolic factors and cancer outcomes, this study seeks to dissect the intricate accumulation and interaction of various metabolic factors in the pathogenesis of digestive system cancers. Additionally, it will quantify the modifying effects of genetic and environmental factors to enhance our understanding of the molecular mechanisms driving cancer progression. The findings will contribute to a more comprehensive understanding of the relationship between metabolism and cancer, identify novel therapeutic targets, and support early prevention and treatment strategies.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17043 | Association between female reproductive factors and new-onset pancreatic cancer risk: a prospective cohort study. | Shuai Xiang (+5) | 2025 | European Journal of Cancer Prevention |
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