| Title: | Study of risk and prognostic factors related to age-related disease and explore the role of physical activity in this relationship |
| Lead Institution: | Naval Medical University |
| Principal investigator: |
Application 827885
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About
The global rise in aging populations presents one of the most significant medical and social challenges of our time. Older adults are increasingly susceptible to age-related diseases such as cardiovascular, respiratory, and mental health disorders. However, the complex interplay of biological, environmental, and lifestyle factors contributing to the development and progression of these conditions remains insufficiently understood. In particular, the role of physical activity as a potential modifier of risk and prognostic outcomes warrants further investigation. This project aims to systematically identify key risk and prognostic factors associated with age-related diseases through large-scale population studies. We will analyze how these factors-individually and in combination-affect health outcomes and examine how demographic variables such as age, gender, and socioeconomic status influence disease risk and progression. A central focus of this study is to explore how physical activity may mediate or moderate these relationships and serve as a protective factor. Furthermore, we seek to identify early clinical or biological markers that can predict the course of age-related diseases. By clarifying the risk landscape and the prognostic significance of various contributing factors-especially physical activity-this research will contribute to the development of targeted prevention strategies and personalized interventions. Ultimately, our findings aim to support public health efforts and empower older adults to maintain health and quality of life as they age.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 21245 | Long-term neurological outcomes of burn injury and the potential mediating role of plasma metabolite profiles and brain structural alterations: a prospective cohort study | Rui Feng (+3) | 2026 | Burns |
Enabling scientific discoveries that improve human health