| Title: | Lifestyles, Environmental Exposures, and Psychological Factors, and Genetic-Environmental Relationships in Aging-Related Diseases |
| Lead Institution: | Xiangya Hospital of Central South University |
| Principal investigator: | Professor Yong Ping Bai |
Application 84443
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About
Aging-related diseases are chronic disorders prevalent in older people, including cardiovascular diseases, diabetes, hypertension, chronic kidney disease, etc., and caused a majority of global disease burden. Although plenty of observational studies analyzed the associations of healthy lifestyles, environmental exposures, and psychological factors with aging-related diseases outcome, the causal relationships between some of them remain unknown. In addition, considering the common involvement of environmental and genetic factors in aging-related chronic diseases, we also want to explore the interaction between external factors and genetic susceptibility with aging-related diseases. Therefore, we would like to use the genetic data from UK Biobank to establish causal associations of lifestyles, environmental exposures, and psychological factors with aging-related diseases, and test for their gene × environment interactions. The outcomes are expected to provide us novel clue for the prevention of aging-related diseases with great clinical benefits. We anticipate the project duration to be 36 months.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9867 | Association between longitudinal change of sleep patterns and the risk of cardiovascular diseases | Lingfang He (+4) | 2024 | Sleep |
| 11442 | Frailty, an Independent Risk Factor in Progression Trajectory of Cardiometabolic Multimorbidity: A Prospective Study of UK Biobank | Tianqi Ma (+7) | 2023 | The Journals of Gerontology Series A |
| 8651 | Genome-wide association study of cardiometabolic multimorbidity in the UK Biobank | Chenxuan Zhao (+4) | 2024 | Clinical Genetics |
Enabling scientific discoveries that improve human health