| Title: | Validation of Novel Candidate Breast Cancer Susceptibility Genes |
| Lead Institution: | Women's College Hospital |
| Principal investigator: | Dr Mohammad Reza Akbari |
Application 85529
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About
Breast cancer is the most frequent malignancy and the first leading cause of cancer-related mortalities in women globally. Multiple risk factors are involved in the etiology of breast cancer, among which genetic factors have a significant role in susceptibility to the disease. In search for novel breast cancer susceptibility genes, our team at Women's College Hospital has recently identified four candidate susceptibility genes among the Polish and Bahamian founder populations. we aim to evaluate the association of the four novel candidate genes identified among the Polish and Bahamian populations with breast cancer risk among other populations. We expect to complete this study in 36 months inckuding the laboratory functional analysis that we are currently performing on these genes and their mutatnts. This study will significantly improve our knowledge of hereditary breast cancer genetics. Given that any of the four candidate genes discovered among the Polish and Bahamian populations are ultimately validated as breast cancer susceptibility gene(s), it will greatly contribute to reducing the unexplained component of hereditary breast cancer landscape. Identifying new breast cancer genetic determinants will empower us to better detect individuals with a higher risk of developing breast cancer through genetic screening measures which will allow for cost-effective, tailored preventive strategies for carriers.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11245 | Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank | Cezary Cybulski (+20) | 2023 | American Journal of Human Genetics |
Enabling scientific discoveries that improve human health