| Application: | 15856, The association of physical activity measured by accelerometry with major disease endpoints |
| Title: | Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96 706 UK Biobank participants |
| Size: | 524497 B |
| Archived: | 16 Dec 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
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Notes
This study of over 96,000 UK men and women from the UK Biobank, who were in the accelerometry subsample, of average age 64.5 years, found that those with chronic conditions are spending considerably less time on physical activity than their healthy peers. Healthy participants spent over an hour more on moderate activity (e.g. brisk walking and gardening), and three minutes (11%) more on vigorous activity (e.g. running and aerobics) a week than those with chronic disease. Participants with mental health disorders had the lowest moderate activity levels of all, spending 2.5 hours less per week than the average 11.8 hours of healthy peers. Participants with cardiovascular diseases had the lowest vigorous activity at 23.1 minutes/week compared to their healthy peers who engaged in 27.0 minutes/week of vigorous activity. Given the substantial health benefits of being physically active, clinicians and policymakers should be aware that their patients with any chronic disease are at greater health risk from other diseases than anticipated because of their physical inactivity.Application 15856
The association of physical activity measured by accelerometry with major disease endpoints
The inclusion of accelerometry as a measure on 100,000 UK Biobank Participants since 2012, and the recent development of a usable measure of physical activity based on it, provides a unique opportunity to improve understanding of the relationship of physical activity (PA) to major disease endpoints. With the completion of linkage of subject data on death, hospital admission, and cancer registry, data by the end of 2015 we will be in a position to test the hypotheses that PA measured objectively is associated with mortality, CVD incidence, and cancer incidence - particularly for bowel, breast and prostate cancer. UK Biobank was established to provide opportunities to explore the relationship of environmental factors and their interaction with genes in the causation of disease. This project seeks to do just that for an important lifestyle variable - physical activity. What we are endeavouring to achieve can only be undertaken at this point with the unique resource that UK Biobank provides - the cutting edge lifestyle measure (PA), relevant genetic measures to permit the examination of gene-environment interactions, and the number of subjects to provide adequate power to undertake this investigation. We will investigate the association of physical activity, measured in the most up to date way using movement monitors, with the major causes of death - cardiovascular disease and cancer. To better understand how physical activity might relate to risk of these diseases we will also examine whether the person's genetic background might influence the way in which physical activity contributes to risk. We intend to examine data on the 100,000 subjects in the cohort that have used accelerometers since 2012
| Lead investigator: | Professor Terence Dwyer |
| Lead institution: | University of Oxford |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3077 | Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96 706 UK Biobank participants | Joseph Barker (+7) | 2019 | International Journal of Epidemiology |
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