| Application: | 27412, Boosting the power of GWAS using novel statistical tools |
| Title: | Common brain disorders are associated with heritable patterns of apparent aging of the brain |
| Size: | 1748 B |
| Archived: | 18 Jan 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3112
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Notes
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3 96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.Application 27412
Boosting the power of GWAS using novel statistical tools
This proposal seeks to apply UK Biobank data to study the genetic architecture of human traits using novel statistical tools. We aim to investigate the relationship between mental disorders and co-morbid diseases such as cardiovascular disease, cancer and metabolic disease (as well as protective phenotypes). Genome-wide association studies (GWAS) have successfully identified many genetic variants influencing complex human traits. However, the identified genetic variants only explain a small portion of the heritability of these traits. To improve discovery of genetic variants in complex human traits, we have developed statistical tools building on a Bayesian statistical framework. This proposal seeks to increase discovery of genetic loci influencing a range of human traits and disorders. Identifying genetic factors that confer risk or protect against health-related traits is critical for understanding the causal mechanisms underlying disease, and the causal relationship shared between clinical conditions. Improved gene discovery might inform the development of genetic prediction tools and ultimately improve treatment strategies for large patient groups. Hence, the proposed research is entirely congruent with the stated aim of UK Biobank ?to improve the prevention, diagnosis and treatment of illness and the promotion of health throughout society?. We will analyze the GWAS data on complex traits in the UK Biobank cohort using novel statistical methodology. Using software and computational tools we are able to enhance gene discovery by integrating GWAS data with additional knowledge about genetic variants, including their association in related traits or their genomic position. To assess the replicability (i.e. the robustness of the results) of the identified variants, we will evaluate their association in independent GWAS cohorts. Finally, the results may inform the development of novel genetic prediction tools. We would wish to study the full UK Biobank cohort.
| Lead investigator: | Professor Ole Andreassen |
| Lead institution: | University of Oslo |
2 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3110 | 27412 | Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes | 15 Jan 2021 |
| 4183 | 27412 | Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology | 2 Nov 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3113 | Common brain disorders are associated with heritable patterns of apparent aging of the brain | Kaufmann T et al. | 2019 | Nat Neurosci |
Enabling scientific discoveries that improve human health