| Application: | 53799, Impact of genetic and environmental factors on the health-related outcomes in chronic kidney disease patients |
| Title: | Causal effects of education on chronic kidney disease: a Mendelian randomization study |
| Size: | 3.4 MB |
| Archived: | 20 May 2021 |
| Stability: | Complete |
| Personal: | Contains individual-level data |
Return 3426
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Notes
Poor socio-economic status, including low education attainment, has been reported in chronic kidney disease (CKD) patients. We aimed to investigate the causal effects of education attainment on the risk of CKD.The study was an observational cohort study including Mendelian randomization (MR) analysis. First, the clinical association between education attainment years as the exposure and prevalent CKD Stages 3-5 as the outcome was investigated by multivariable logistic regression in 308 741 individuals 40-69 years of age from the UK Biobank. MR analysis was performed with a previously reported genetic instrument from a genome-wide association meta-analysis of education attainment. Two-sample MR was performed with summary statistics for CKD in 567 460 individuals with European ancestry in the CKDGen genome-wide association meta-analysis. The findings were replicated by allele score based MR in 321 260 individuals of white British ancestry in the UK Biobank with quality-controlled genetic data.
Higher education attainment was significantly associated with lower adjusted odds for CKD in the clinical analysis {>17 years versus <16 years, adjusted odds ratio [OR] 0.910 [95% confidence interval (CI) 0.849-0.975]}. The causal estimates obtained by the inverse variance method in the two-sample MR indicated that higher genetically predicted education attainment causally reduced the risk of CKD [OR 0.934 (95% CI 0.873-0.999)]. Allele score based MR also supported that higher education attainment was causally linked to a decreased risk of CKD [adjusted OR 0.944 (95% CI 0.922-0.966)].
The study suggests that higher education attainment causally reduces the risk of CKD development in the general population.
Application 53799
Impact of genetic and environmental factors on the health-related outcomes in chronic kidney disease patients
Chronic kidney disease (CKD) is a prevalent chronic disease which possesses considerable medical burden as significant portion of CKD patients progress to end-stage renal disease (ESRD) or complicated with various adverse health-related complications. It is pivotal for clinicians to focus on reducing such complications, as cardiovascular disease is the major cause of death among them. Both environmental and genetic factors may contribute to the progression to ESRD or development of adverse complications. Nevertheless, thorough investigations regarding which patients possess the elevated risks had not been evaluated yet. We plan to perform the present study to stratify CKD patients according to the risk of progression to ESRD and the risk of developing adverse outcomes, including cardiovascular events and cancer. We have undergone several studies using the nationwide data of Korean National Health Insurance System andgovernment-funded prospective cohort dataset called Korean Genome and Epidemiology Study to examine the role of genetic and environmental factors in various chronic diseases.. During the next 36 months with the project using the Biobank data, we aim to demonstrate the potential risk factors which contribute most to the development of health-related complications in CKD patients. Mendelian randomization will be applied to test the causality. Moreover, comparative analysis with Korean cohorts will be performed to evaluate the impact of different environmental and genetic factors on the development of adverse outcomes in CKD patients with different ethnicity and also to determine whether the study results could be adapted worldwide. Consequently, the study results may contribute to the preventive health care to reduce the burden of the chronic disease, through informing clinicians how to distinguish the high-risk patients and to minimize health-related adverse outcomes among the applicable patients.
| Lead investigator: | Professor Dong Ki Kim |
| Lead institution: | Seoul National University Hospital |
1 related Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3981 | 53799 | Short or Long Sleep Duration and CKD: A Mendelian Randomization Study | 13 Oct 2021 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3427 | Causal effects of education on chronic kidney disease: a Mendelian randomization study | Park S et al. | 2021 | Clin Kidney J |
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