| Title: | Associations of baseline use of fish oil with progression of cardiometabolic multimorbidity and mortality among patients with hypertension: a prospective study of UK Biobank |
| Journal: | European Journal of Nutrition |
| Published: | 19 May 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35589868/ |
| DOI: | https://doi.org/10.1007/s00394-022-02889-w |
| URL: | https://link.springer.com/content/pdf/10.1007/s00394-022-02889-w.pdf |
Publication 10244
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Abstract
PurposeThe role of fish oil in the prognosis of hypertensive patients is unknown. This study investigated the associations of fish oil supplementation with the progression of cardiometabolic multimorbidity (CMM) and mortality among patients with hypertension.MethodsBased on UK Biobank, we enrolled participants with hypertension and free of other cardiometabolic diseases. The exposure was baseline use of fish oil derived from questionnaires at baseline. The primary outcomes were the incidence of CMM and all-cause mortality. Competing risk models and flexible parametric proportion-hazards models were fitted to assess the adjusted hazard ratios (HRs) for the risk of CMM and mortality outcomes, respectively.ResultsAmong 81,579 participants involved [50.37%, men; mean age, 59.38 years (standard deviation, 7.23 years)], 15,990 CMM events and 6456 all-cause deaths were reported (median follow-up, 12.23 years). In multivariable-adjusted models, baseline use of fish oil was associated with 8% lower risk of CMM [95% confidence interval (95% CI) 0.89-0.96, P < 0.001] and 10% lower risk of all-cause mortality (95% CI 0.85-0.95, P < 0.001).ConclusionIn individuals with hypertension, baseline use of fish oil was associated with a reduced risk of CMM and all-cause mortality, and further clinical trials are needed to prove this hypothesis.</p>
7 Authors
- Tianqi Ma
- Lingfang He
- Yi Luo
- Jinchen Li
- Guogang Zhang
- Xunjie Cheng
- Yongping Bai
1 Application
| Application ID | Title |
|---|---|
| 76118 | Risk and Protective Factors Associated with Cardiometabolic Multimorbidity. |
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