| Title: | Use of fish oil and mortality of patients with cardiometabolic multimorbidity: A prospective study of UK biobank |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 28 Sep 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36319577/ |
| DOI: | https://doi.org/10.1016/j.numecd.2022.09.016 |
Publication 10483
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Abstract
BACKGROUND AND AIMS: Cardiometabolic multimorbidity (CMM) has risen as a global issue of public health, with an in-creasing prevalence and more severe clinical prognosis. This study aimed to estimate the association between use of fish oil and mortality among patients with CMM.</p>
METHODS AND RESULTS: In this prospective study based on UK Biobank, participants with ≥2 of cardiometabolic diseases (CMDs, including coronary heart disease [CHD], diabetes, hypertension, and stroke in this study) at recruitment were included. Use of fish oil was derived from touchscreen questionnaires at baseline. All-cause and cardiovascular mortality were accessed via electronic health-related records. Kaplan-Meier curves and flexible parametric Royston-Parmar proportion-hazard models were fitted to assess the as-sociations of fish-oil use with all-cause, cardiovascular mortality, and related life expectancy alterations. Among 30 068 participants from UK Biobank (67.9% men; mean age 61.75 years), 5357 deaths were reported during 12.03 years of follow-up. For patients with CMM, use of fish oil was associated with a 17% lower risk of all-cause mortality (95% confidence interval [95% CI] 0.78-0.88, P < 0.001), and 19% lower risk of cardiovascular mortality (95% CI 0.72-0.90, P < 0.001) in multivariable-adjusted models. At 45 years old, using fish oil was associated with 1.66 years of life expectancy gained.</p>
CONCLUSION: Among patients with CMM, use of fish oil was associated with a significantly reduced risk of all-cause, cardiovascular mortality, and prolonged life expectancy.</p>
6 Authors
- Tianqi Ma
- Lingfang He
- Yi Luo
- Guogang Zhang
- Xunjie Cheng
- Yongping Bai
1 Application
| Application ID | Title |
|---|---|
| 76118 | Risk and Protective Factors Associated with Cardiometabolic Multimorbidity. |
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