| Title: | Whole Exome Sequencing Study Identifies Novel Rare Risk Variants for Habitual Coffee Consumption Involved in Olfactory Receptor and Hyperphagia |
| Journal: | Nutrients |
| Published: | 16 Oct 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36297015/ |
| DOI: | https://doi.org/10.3390/nu14204330 |
| URL: | https://www.mdpi.com/2072-6643/14/20/4330/pdf?version=1665916563 |
Publication 10579
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Abstract
Habitual coffee consumption is an addictive behavior with unknown genetic variations and has raised public health issues about its potential health-related outcomes. We performed exome-wide association studies to identify rare risk variants contributing to habitual coffee consumption utilizing the newly released UK Biobank exome dataset (n = 200,643). A total of 34,761 qualifying variants were imported into SKAT to conduct gene-based burden and robust tests with minor allele frequency <0.01, adjusting the polygenic risk scores (PRS) of coffee intake to exclude the effect of common coffee-related polygenic risk. The gene-based burden and robust test of the exonic variants found seven exome-wide significant associations, such as OR2G2 (PSKAT = 1.88 × 10−9, PSKAT-Robust = 2.91 × 10−17), VEZT1 (PSKAT = 3.72 × 10−7, PSKAT-Robust = 1.41 × 10−7), and IRGC (PSKAT = 2.92 × 10−5, PSKAT-Robust = 1.07 × 10−7). These candidate genes were verified in the GWAS summary data of coffee intake, such as rs12737801 (p = 0.002) in OR2G2, and rs34439296 (p = 0.008) in IRGC. This study could help to extend genetic insights into the pathogenesis of coffee addiction, and may point to molecular mechanisms underlying health effects of habitual coffee consumption.</p>
10 Authors
- Bolun Cheng
- Chuyu Pan
- Shiqiang Cheng
- Peilin Meng
- Li Liu
- Wenming Wei
- Xuena Yang
- Yumeng Jia
- Yan Wen
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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