| Title: | Mitral Annular Disjunction Assessed Using CMR Imaging Insights From the UK Biobank Population Study |
| Journal: | JACC Cardiovascular Imaging |
| Published: | 19 Oct 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36280553/ |
| DOI: | https://doi.org/10.1016/j.jcmg.2022.07.015 |
| URL: | https://ars.els-cdn.com/content/image/1-s2.0-S1936878X2200479X-fx1_lrg.jpg |
| Citations: | 43 (40 in last 2 years) as of 8 Aug 2024 |
Publication 10605
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Mitral annular disjunction is the atrial displacement of the mural mitral valve leaflet hinge point within the atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in the general population is not known.</p>
OBJECTIVES: The purpose of this study was to assess the frequency of occurrence and extent of mitral annular disjunction in a large population cohort.</p>
METHODS: The authors assessed the cardiac magnetic resonance (CMR) images in 2,646 Caucasian subjects enrolled in the UK Biobank imaging study, measuring the length of disjunction at 4 points around the mitral annulus, assessing for presence of prolapse or billowing of the leaflets, and for curling motion of the inferolateral left ventricular wall.</p>
RESULTS: From 2,607 included participants, the authors found disjunction in 1,990 (76%) cases, most commonly at the anterior and inferior ventricular wall. The authors found inferolateral disjunction, reported as clinically important, in 134 (5%) cases. Prolapse was more frequent in subjects with disjunction (odds ratio [OR]: 2.5; P = 0.02), with positive associations found between systolic curling and disjunction at any site (OR: 3.6; P < 0.01), and systolic curling and prolapse (OR: 71.9; P < 0.01).</p>
CONCLUSIONS: This large-scale study shows that disjunction is a common finding when using CMR. Disjunction at the inferolateral ventricular wall, however, was rare. The authors found associations between disjunction and both prolapse and billowing of the mural mitral valve leaflet. These findings support the notion that only extensive inferolateral disjunction, when found, warrants consideration of further investigation, but disjunction elsewhere in the annulus should be considered a normal finding.</p>
7 Keywords
- Biological Specimen Banks
- Humans
- Mitral Valve
- Mitral Valve Prolapse
- Predictive Value of Tests
- Prolapse
- United Kingdom
12 Authors
- Dasa Zugwitz
- Kenneth Fung
- Nay Aung
- Elisa Rauseo
- Celeste McCracken
- Jackie Cooper
- Saloua El Messaoudi
- Robert H. Anderson
- Stefan K. Piechnik
- Stefan Neubauer
- Steffen E. Petersen
- Robin Nijveldt
1 Application
| Application ID | Title |
|---|---|
| 2964 | Description of cardiovascular phenotype in the UK Biobank population based on cardiovascular magnetic resonance and carotid ultrasound |
Enabling scientific discoveries that improve human health