| Title: | Automated imaging-based abdominal organ segmentation and quality control in 20,000 participants of the UK Biobank and German National Cohort Studies |
| Journal: | Scientific Reports |
| Published: | 4 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36333523/ |
| DOI: | https://doi.org/10.1038/s41598-022-23632-9 |
| URL: | https://www.nature.com/articles/s41598-022-23632-9.pdf |
Publication 10660
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Abstract
Large epidemiological studies such as the UK Biobank (UKBB) or German National Cohort (NAKO) provide unprecedented health-related data of the general population aiming to better understand determinants of health and disease. As part of these studies, Magnetic Resonance Imaging (MRI) is performed in a subset of participants allowing for phenotypical and functional characterization of different organ systems. Due to the large amount of imaging data, automated image analysis is required, which can be performed using deep learning methods, e. g. for automated organ segmentation. In this paper we describe a computational pipeline for automated segmentation of abdominal organs on MRI data from 20,000 participants of UKBB and NAKO and provide results of the quality control process. We found that approx. 90% of data sets showed no relevant segmentation errors while relevant errors occurred in a varying proportion of data sets depending on the organ of interest. Image-derived features based on automated organ segmentations showed relevant deviations of varying degree in the presence of segmentation errors. These results show that large-scale, deep learning-based abdominal organ segmentation on MRI data is feasible with overall high accuracy, but visual quality control remains an important step ensuring the validity of down-stream analyses in large epidemiological imaging studies.</p>
25 Authors
- Turkay Kart
- Marc Fischer
- Stefan Winzeck
- Ben Glocker
- Wenjia Bai
- Robin Bülow
- Carina Emmel
- Lena Friedrich
- Hans-Ulrich Kauczor
- Thomas Keil
- Thomas Kröncke
- Philipp Mayer
- Thoralf Niendorf
- Annette Peters
- Tobias Pischon
- Benedikt M. Schaarschmidt
- Börge Schmidt
- Matthias B. Schulze
- Lale Umutle
- Henry Völzke
- Thomas Küstner
- Fabian Bamberg
- Bernhard Schölkopf
- Daniel Rueckert
- Sergios Gatidis
1 Application
| Application ID | Title |
|---|---|
| 12579 | Machine Learning for Abnormality Detection in Imaging Studies with Application to Auto-QC and Identification of Pathology-specific Outliers through Correlation with Non-Image Data |
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