| Title: | Sleep duration and daytime napping in relation to incident inflammatory bowel disease: a prospective cohort study |
| Journal: | Alimentary Pharmacology & Therapeutics |
| Published: | 9 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36352835/ |
| DOI: | https://doi.org/10.1111/apt.17285 |
| Citations: | 11 (11 in last 2 years) as of 8 Aug 2024 |
Publication 10675
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Sleep dysregulation has been linked to gastrointestinal dysfunction and inflammation.</p>
AIMS: To explore the associations between sleep duration, daytime napping and inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC).</p>
METHODS: Exposure information was obtained from the baseline questionnaire. Sleep duration was coded as continuous and categorical (≤5, 6, 7, 8, ≥9 h/day) variables. Daytime napping was defined as yes (sometimes/usually) and no (never/rarely). Incident IBD cases were defined from primary care and hospital inpatient records. Polygenic risk scores (PRS) for the outcomes were constructed and categorised into low, intermediate and high risk. Hazard ratio (HR) and confidence interval (CI) were estimated using Cox proportional hazard regression.</p>
RESULTS: The analysis included 2604 incident IBD cases (806 CD and 1798 UC) with a median follow-up of 12.0 years. Comparing sleep duration ≤5 with 7 h/day, the HR of IBD, CD and UC was 1.36 (95% CI, 1.17-1.59), 1.53 (95% CI, 1.17-2.00) and 1.29 (95% CI, 1.07-1.56), respectively. Comparing participants with and without daytime napping, the HR of IBD, CD and UC was 1.13 (95% CI, 1.05-1.23), 1.25 (95% CI, 1.08-1.44) and 1.09 (95% CI, 0.90-1.20), respectively. No interaction of sleep duration and daytime napping with PRS was detected. However, the associations appeared stronger in individuals with high rather than low PRS.</p>
CONCLUSIONS: This study reveals positive associations between short sleep duration and daytime napping and IBD risk.</p>
15 Authors
- Shuai Yuan
- Yuhao Sun
- Xiao Tan
- Jiawei Geng
- Jing Sun
- Xuejie Chen
- Lili Yu
- Jiayi Wang
- Xuan Zhou
- Therese Hesketh
- Susanna C. Larsson
- Jie Chen
- Xiaoyan Wang
- Xue Li
- Zhanju Liu
1 Application
| Application ID | Title |
|---|---|
| 66354 | Investigating the genetic, environmental and clinical determinants and their interactions on cancer risk, and developing risk prediction and prognosis models for common cancer types |
Enabling scientific discoveries that improve human health