| Title: | Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank |
| Journal: | Nature Communications |
| Published: | 3 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36737450/ |
| DOI: | https://doi.org/10.1038/s41467-023-36231-7 |
| URL: | https://www.nature.com/articles/s41467-023-36231-7.pdf |
Publication 11040
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Abstract
Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 participants in the UK Biobank. The biomarkers cover 249 measures of lipoprotein lipids, fatty acids, and small molecules such as amino acids, ketones, and glycolysis metabolites. We provide an atlas of associations of these biomarkers to prevalence, incidence, and mortality of over 700 common diseases (nightingalehealth.com/atlas). The results reveal a plethora of biomarker associations, including susceptibility to infectious diseases and risk of various cancers, joint disorders, and mental health outcomes, indicating that abundant circulating lipids and metabolites are risk markers beyond cardiometabolic diseases. Clustering analyses indicate similar biomarker association patterns across different disease types, suggesting latent systemic connectivity in the susceptibility to a diverse set of diseases. This work highlights the value of NMR based metabolic biomarker profiling in large biobanks for public health research and translation.</p>
16 Authors
- Heli Julkunen
- Anna Cichońska
- Mika Tiainen
- Harri Koskela
- Kristian Nybo
- Valtteri Mäkelä
- Jussi Nokso-Koivisto
- Kati Kristiansson
- Markus Perola
- Veikko Salomaa
- Pekka Jousilahti
- Annamari Lundqvist
- Antti J. Kangas
- Pasi Soininen
- Jeffrey C. Barrett
- Peter Würtz
1 Application
| Application ID | Title |
|---|---|
| 30418 | Biomarker profiling by NMR metabolomics for the study of chronic disease risk and underlying risk factors |
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