| Title: | Lower omega-3 status associated with higher erythrocyte distribution width and neutrophil-lymphocyte ratio in UK Biobank cohort |
| Journal: | Prostaglandins Leukotrienes and Essential Fatty Acids |
| Published: | 16 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36934703/ |
| DOI: | https://doi.org/10.1016/j.plefa.2023.102567 |
| URL: | https://doi.org/10.1101/2022.12.09.22283290 |
Publication 11212
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
High red blood distribution width (RDW) is associated with decreased red blood cell deformability, and high neutrophil-lymphocyte ratio (NLR) is a biomarker of systemic inflammation and innate-adaptive immune system imbalance. Both RDW and NLR are predictors of chronic disease risk and mortality. Omega-3 index (O3I) values have previously been shown to be inversely associated with RDW and NLR levels. Our objective was to determine if total plasma long chain omega-3 fatty acids (Omega3%) measured in the UK Biobank cohort were associated with RDW and NLR values. RDW- and NLR- relationships with Omega3% were characterized in 109,191 adults (58.4% female). RDW- and NLR-Omega3% relationships were inversely associated with Omega3% (both p < 0.0001). These cross-sectional associations confirm previous findings that increasing RDW and NLR values are associated with low O3I. The hypothesis that RDW and/or NLR values can be reduced in individuals with less-than optimal long chain omega 3 values need to be tested in randomized controlled intervention trials using EPA and/or DHA.</p>
3 Authors
- Michael I McBurney
- Nathan L Tintle
- William S Harris
Enabling scientific discoveries that improve human health