| Title: | Lower omega-3 status associated with higher erythrocyte distribution width and neutrophil-lymphocyte ratio in UK Biobank cohort |
| Journal: | Prostaglandins Leukotrienes and Essential Fatty Acids |
| Published: | 16 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36934703/ |
| DOI: | https://doi.org/10.1016/j.plefa.2023.102567 |
| URL: | https://doi.org/10.1101/2022.12.09.22283290 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 11212
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Abstract
High red blood distribution width (RDW) is associated with decreased red blood cell deformability, and high neutrophil-lymphocyte ratio (NLR) is a biomarker of systemic inflammation and innate-adaptive immune system imbalance. Both RDW and NLR are predictors of chronic disease risk and mortality. Omega-3 index (O3I) values have previously been shown to be inversely associated with RDW and NLR levels. Our objective was to determine if total plasma long chain omega-3 fatty acids (Omega3%) measured in the UK Biobank cohort were associated with RDW and NLR values. RDW- and NLR- relationships with Omega3% were characterized in 109,191 adults (58.4% female). RDW- and NLR-Omega3% relationships were inversely associated with Omega3% (both p < 0.0001). These cross-sectional associations confirm previous findings that increasing RDW and NLR values are associated with low O3I. The hypothesis that RDW and/or NLR values can be reduced in individuals with less-than optimal long chain omega 3 values need to be tested in randomized controlled intervention trials using EPA and/or DHA.</p>
3 Authors
- Michael I McBurney
- Nathan L Tintle
- William S Harris
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