| Title: | The sulfur microbial diet and increased risk of obesity: Findings from a population-based prospective cohort study |
| Journal: | Clinical Nutrition |
| Published: | 17 Mar 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37003050/ |
| DOI: | https://doi.org/10.1016/j.clnu.2023.03.011 |
| Citations: | 8 (8 in last 2 years) as of 8 Aug 2024 |
Publication 11214
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Abstract
BACKGROUND & AIMS: Gut-produced hydrogen sulfide (H2S) has been associated with increased gut permeability and inflammation, which may be related to higher obesity risk. We investigated the association of sulfur microbial diet, a dietary index associated with 43 sulfur-metabolizing bacteria, with the incident obesity and whether the relationship was modified by the genetic predisposition to obesity.</p>
METHODS: We included 27,429 participants with available body mass index (BMI) data from the UK Biobank. The sulfur microbial diet score was assessed using the 24-h dietary assessment method. Obesity and abdominal obesity were defined according to the World Health Organization criteria. Body fat percentage was assessed using a body composition analyzer. The genetic risk score (GRS) was calculated by 940 BMI-related variants.</p>
RESULTS: We documented 1472 and 2893 cases of obesity and abdominal obesity during a mean follow-up of 8.1 years. After multivariable adjustment, the sulfur microbial diet score was positively associated with obesity (HRQ4vsQ1 = 1.63; 95% CI = 1.40-1.89, P-trend = 0.001) and abdominal obesity risk (HRQ4vsQ1 = 1.17; 95% CI = 1.05-1.30, P-trend = 0.002). We also observed that increased sulfur microbial diet score was positively related to several adiposity indicators, including a 5% increase in BMI, WC, and body fat percentage. Moreover, the sulfur microbial diet had no significant interactions with genetic risk on obesity incidence.</p>
CONCLUSIONS: Our results emphasized the significance of avoiding the sulfur microbial diet for obesity prevention across all levels of genetic risk.</p>
9 Authors
- Xiaohui Liu
- Xuzhi Wan
- Lange Zhang
- Yin Li
- Yang Ao
- Pan Zhuang
- Yuqi Wu
- Yu Zhang
- Jingjing Jiao
1 Application
| Application ID | Title |
|---|---|
| 47365 | Dietary patterns and genetic predisposition to obesity, type 2 diabetes, and cardiovascular disease. |
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