| Title: | Determinants of Incident Atherosclerotic Cardiovascular Disease Events and All-Cause Mortality in Patients With Age-Related Macular Degeneration: Prospective Cohort Study of UK Biobank |
| Journal: | Asia-Pacific Journal of Ophthalmology |
| Published: | 31 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37249901/ |
| DOI: | https://doi.org/10.1097/apo.0000000000000612 |
Publication 11513
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Abstract
PURPOSE: Major risk factors of atherosclerotic cardiovascular disease (ASCVD) and mortality have been well-established in the general population. Our study is aimed at assessing longitudinal relationships between ASCVD risk factors and incident ASCVD events or all-cause mortality in patients with age-related macular degeneration (AMD).</p>
METHODS: Multivariable-adjusted Cox proportional hazards models were used to study the association between cardiovascular risk factors with adjudicated incident ASCVD events and all-cause mortality outcomes followed until 2021. A restricted cubic spline approach was utilized to assess nonlinear associations between potential cardiovascular risk factors and ASCVD or mortality.</p>
RESULTS: We identified 3508 eligible patients [mean (SD) age = 61.45 (6.43) years; 37.76% males] with AMD at baseline. During a median follow-up year of 12, there were 110 cases of ASCVD events and 186 cases of all-cause mortality. After multivariable adjustment, each 10 U/L increase of serum gamma-glutamyl transferase level was linearly associated with incident ASCVD [hazard ratio (HR) = 1.03, 95% CI = 1.00-1.07, Pnonlinear = 0.85)] in AMD. A history of chronic kidney disease (HR = 1.94, 95% CI = 1.09-3.46) and lower vitamin D [HR = 0.98, 95% CI = 0.97-0.99, per nanomoles per liter (nmol/L)] were significantly associated with all-cause mortality in patients with AMD, with the association between vitamin D and all-cause mortality presenting a U shape (Pnonlinear = 0.02). In contrast, risk factors significantly associated with ASCVD and all-cause mortality in healthy controls differed from patients with AMD.</p>
CONCLUSIONS: Our findings demonstrate risk factors associated with ASCVD events and all-cause mortality among individuals with AMD differed from healthy controls and suggest the long-term management of risk factors in patients with AMD.</p>
15 Authors
- Yaxin Wang
- Yingying Liang
- Ishith Seth
- Guanrong Wu
- Zijing Du
- Yu Huang
- Xianwen Shang
- Shunming Liu
- Yunyan Hu
- Ying Fang
- Zhuoting Zhu
- Yijun Hu
- Xiayin Zhang
- Xiaohong Yang
- Honghua Yu
1 Application
| Application ID | Title |
|---|---|
| 62525 | The eye and aging |
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