| Title: | Habitual fish oil use and risk of COVID-19-related outcomes: Evidence from a large scale cohort study and Mendelian randomization analysis |
| Journal: | Clinical Nutrition |
| Published: | 6 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37429103/ |
| DOI: | https://doi.org/10.1016/j.clnu.2023.07.001 |
| URL: | http://www.clinicalnutritionjournal.com/article/S0261561423002182/pdf |
Publication 11620
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Abstract
BACKGROUND & AIMS: Previous findings for the effects of fish oil on COVID-19-related outcomes remain largely inconclusive and controversy persists. Large population-based studies in real-life settings are required to explore the impact of habitual fish oil use on Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, Coronavirus disease 2019 (COVID-19)-related hospitalization and death. To investigate the associations between habitual fish oil use and SARS-CoV-2infection, COVID-19-related outcome.</p>
METHODS: Cohort study based on the UK Biobank. 466,572 participants were enrolled. For Mendelian randomization (MR) study, single-nucleotide variants were selected for exposures of fish-oil-derived n-3 PUFAs, including docosapentaenoic acid (DPA).</p>
RESULTS: 146,969 (31.5%) participants reported their habitual fish oil use at baseline. Compared with non-fish-oil-users, the hazard ratios for habitual users were 0.97 (95% confidence interval [CI] 0.94 to 0.99) for SARS-CoV-2 infection, 0.92 (95% CI 0.85 to 0.98) for COVID-19-related hospitalization and 0.86 (95% CI 0.75 to 0.98) for COVID-19-related death. MR showed that a higher level of circulating DPA is casually associated with a lower risk of severe COVID-19 (IVW, odds ratio = 0.26, 95% CI 0.08-0.88, P = 0.030).</p>
CONCLUSIONS: In this large cohort, we found that habitual fish oil use was significantly associated with lower risks of SARS-CoV-2 infection, hospitalization and death from COVID-19. MR analyses further support a possible causal role of DPA, one of the components of fish oil and valid biomarkers of dietary intake, in reducing the risk of severe COVID-19.</p>
13 Authors
- Yuying Ma
- Lijun Zhang
- Ruijie Zeng
- Rui Jiang
- Dongling Luo
- Huihuan Wu
- Zewei Zhuo
- Qi Yang
- Jingwei Li
- Felix W Leung
- Chongyang Duan
- Weihong Sha
- Hao Chen
1 Application
| Application ID | Title |
|---|---|
| 83339 | Characterization of risk factors and biomarkers for digestive tract diseases |
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