| Title: | Circulating hormones and risk of gastric cancer by subsite in three cohort studies |
| Journal: | Gastric Cancer |
| Published: | 16 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37455285/ |
| DOI: | https://doi.org/10.1007/s10120-023-01414-0 |
| URL: | https://link.springer.com/content/pdf/10.1007/s10120-023-01414-0.pdf |
Publication 11632
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Abstract
BackgroundObesity has been positively associated with gastric cancer. Excess fat impacts hormones, which have been implicated in carcinogenesis. We investigated obesity-related hormones and cardia gastric cancer (CGC) and non-cardia gastric cancer (NCGC) risk.MethodsNested case-control studies were conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (61 CGCs, and 172 NCGCs and matched controls) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study (100 CGCs and 65 NCGCs and matched controls); serum hormones were measured. In UK-Biobank (n = 458,713), we included 137 CGCs and 92 NCGCs. Sex-specific analyses were conducted. For EPIC and ATBC, odds ratios (ORs), and for UK-Biobank hazard ratios (HRs), were estimated using conditional logistic regression and Cox regression, respectively.ResultsInsulin-like growth-factor-1 was positively associated with CGC and NCGC in EPIC men (ORper 1-SD increase 1.94, 95% CI 1.03-3.63; ORper 1-SD increase 1.63, 95% CI 1.05-2.53, respectively), with similar findings for CGC in UK-Biobank women (HRper 1-SD increase 1.76, 95% CI 1.08-2.88). Leptin in EPIC men and C-peptide in EPIC women were positively associated with NCGC (ORT3 vs. T1 2.72, 95% CI 1.01-7.34 and ORper 1-SD increase 2.17, 95% CI 1.19-3.97, respectively). Sex hormone-binding globulin was positively associated with CGC in UK-Biobank men (HRper 1-SD increase 1.29, 95% CI 1.02-1.64). Conversely, ghrelin was inversely associated with NCGC among EPIC and ATBC men (ORper 1-SD increase 0.53, 95% CI 0.34-0.84; ORper 1-SD increase 0.22, 95% CI 0.10-0.50, respectively). In addition, dehydroepiandrosterone was inversely associated with CGC in EPIC and ATBC men combined.ConclusionsSome obesity-related hormones influence CGC and NCGC risk.</p>
15 Authors
- Harinakshi Sanikini
- Carine Biessy
- Sabina Rinaldi
- Anne-Sophie Navionis
- Audrey Gicquiau
- Pekka Keski-Rahkonen
- Agneta Kiss
- Stephanie J. Weinstein
- Demetrius Albanes
- Antonio Agudo
- Mazda Jenab
- Elio Riboli
- Marc J. Gunter
- Gwen Murphy
- Amanda J. Cross
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