| Title: | The predictive value of cardiovascular outcomes and mortality assessed by the C-reactive protein to albumin ratio in the UK Biobank |
| Journal: | BMC Cardiovascular Disorders |
| Published: | 26 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38926672/ |
| DOI: | https://doi.org/10.1186/s12872-024-03995-9 |
| URL: | https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/s12872-024-03995-9 |
Publication 11785
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Abstract
BackgroundThe C-reactive protein/albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly in elderly patients, yet less is known about if CAR is superior to C-reactive protein (CRP) in the general population.MethodsProspective study design on the UK Biobank, where serum samples of CRP and Albumin were used. Cox regression analyses were conducted to assess all-cause and cardiovascular mortality, myocardial infarction, ischemic stroke, and heart failure over a follow-up period of approximately 12.5 years. The Cox model was adjusted for established cardiovascular disease (CVD) risk factors, including age, sex, smoking habits, physical activity level, BMI level, systolic blood pressure, LDL-cholesterol, statin treatment, diabetes, and previous CVD, with hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Analyses were also stratified by sex, CRP level (< 10 and ≥ 10 mg/ml) and age (< 60 and ≥ 60 years).ResultsIn total, 411,506 individuals (186,043 men and 225,463 women) were included. In comparisons between HRs for all adverse outcomes, the results were similar or identical for CAR and CRP. For example, both CAR and CRP, adjusted HRs for all-cause mortality were 1.13 (95% CI 1.12-1.14). Regarding CVD mortality, the adjusted HR for CAR was 1.14 (95% CI 1.12-1.15), while for CRP, it was 1.13 (95% CI 1.11-1.15).ConclusionsWithin this study CAR was not superior to CRP in predictive ability of mortality or CVD disorders.Clinical trial registration numberNot applicable (cohort study).</p>
21 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Biomarkers
- C-Reactive Protein
- Cardiovascular Diseases
- Cause of Death
- Female
- Heart Disease Risk Factors
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Serum Albumin, Human
- Time Factors
- UK Biobank
- United Kingdom
6 Authors
- Per Wändell
- Axel C Carlsson
- Anders O Larsson
- Johan Ärnlöv
- Toralph Ruge
- Andreas Rydell
1 Application
| Application ID | Title |
|---|---|
| 81508 | The role of lifestyle including physical activity, pain, -omics biomarkers and genetics in cardiovascular disease and kidney function |
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