| Title: | Advantageous early-life environments cushion the genetic risk for ischemic heart disease |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 25 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38917008/ |
| DOI: | https://doi.org/10.1073/pnas.2314056121 |
| URL: | https://cris.unibo.it/bitstream/11585/973054/3/baker-et-al-2024-advantageous-early-life-environments-cushion-the-genetic-risk-for-ischemic-heart-disease.pdf |
Publication 11795
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Abstract
In one of the first papers on the impact of early-life conditions on individuals' health in older age, Barker and Osmond [Lancet, 327, 1077-1081 (1986)] show a strong positive relationship between infant mortality rates in the 1920s and ischemic heart disease in the 1970s. We merge historical data on infant mortality rates to 370,000 individual records in the UK Biobank using information on local area and year of birth. We replicate the association between the early-life infant mortality rate and later-life ischemic heart disease in our sample. We then go "beyond Barker," by showing considerable genetic heterogeneity in this association that is robust to within-area as well as within-family analyses. We find no association between the polygenic index and heart disease in areas with the lowest infant mortality rates, but a strong positive relationship in areas characterized by high infant mortality. These findings suggest that advantageous environments can cushion one's genetic disease risk.</p>
13 Keywords
- Adult
- Aged
- Female
- Genetic Predisposition to Disease
- Humans
- Infant
- Infant Mortality
- Infant, Newborn
- Male
- Middle Aged
- Myocardial Ischemia
- Risk Factors
- United Kingdom
4 Authors
- Samuel Baker
- Pietro Biroli
- Hans van Kippersluis
- Stephanie von Hinke
1 Application
| Application ID | Title |
|---|---|
| 74002 | Developmental Origins: exploring the Nature-Nurture Interplay |
Enabling scientific discoveries that improve human health