| Title: | Accelerometer-Measured Behavior Patterns in Incident Cerebrovascular Disease: Insights for Preventative Monitoring From the UK Biobank |
| Journal: | Journal of the American Heart Association |
| Published: | 31 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38818948/ |
| DOI: | https://doi.org/10.1161/jaha.123.032965 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255632 |
| Citations: | 2 (2 in last 2 years) as of 8 Aug 2024 |
Publication 11941
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Abstract
BACKGROUND: The goal was to compare patterns of physical activity (PA) behaviors (sedentary behavior [SB], light PA, moderate-to-vigorous PA [MVPA], and sleep) measured via accelerometers for 7 days between patients with incident cerebrovascular disease (CeVD) (n=2141) and controls (n=73 938).</p>
METHODS AND RESULTS: In multivariate models, cases spent 3.7% less time in MVPA (incidence rate ratio [IRR], 0.963 [95% CI, 0.929-0.998]) and 1.0% more time in SB (IRR, 1.010 [95% CI, 1.001-1.018]). Between 12 and 24 months before diagnosis, cases spent more time in SB (IRR, 1.028 [95% CI, 1.001-1.057]). Within the year before diagnosis, cases spent less time in MVPA (IRR, 0.861 [95% CI, 0.771-0.964]). Although SB time was not associated with CeVD risk, MVPA time, both total min/d (hazard ratio [HR], 0.998 [95% CI, 0.997-0.999]) and guideline threshold adherence (≥150 min/wk) (HR, 0.909 [95% CI, 0.827-0.998]), was associated with decreased CeVD risk. Comorbid burden had a significant partial mediation effect on the relationship between MVPA and CeVD. Cases slept more during 12:00 to 17:59 hours (IRR, 1.091 [95% CI, 1.002-1.191]) but less during 0:00 to 5:59 hours (IRR, 0.984 [95% CI, 0.977-0.992]). No between-group differences were significant at subgroup analysis.</p>
CONCLUSIONS: Daily behavior patterns were significantly different in patients before CeVD. Although SB was not associated with CeVD risk, the association between MVPA and CeVD risk is partially mediated by comorbid burden. This study has implications for understanding observable behavior patterns in cerebrovascular dysfunction and may help in developing remote monitoring strategies to prevent or reduce cerebrovascular decline.</p>
18 Keywords
- Accelerometry
- Aged
- Biological Specimen Banks
- Case-Control Studies
- Cerebrovascular Disorders
- Exercise
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Sedentary Behavior
- Sleep
- Time Factors
- UK Biobank
- United Kingdom
5 Authors
- Stephanie J. Zawada
- Ali Ganjizadeh
- Gian Marco Conte
- Bart M. Demaerschalk
- Bradley J. Erickson
1 Application
| Application ID | Title |
|---|---|
| 91159 | The association of physical activity with changes in brain volume and carotid artery stiffness in patients at risk for stroke |
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