| Title: | Trajectories of depressive symptoms and risk of cardiovascular disease, cancer and mortality: a prospective cohort study |
| Journal: | General Psychiatry |
| Published: | 17 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38770357/ |
| DOI: | https://doi.org/10.1136/gpsych-2023-101456 |
| URL: | https://gpsych.bmj.com/content/gpsych/37/3/e101456.full.pdf |
Publication 12054
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Background: Depressive symptoms are established risk factors for various health outcomes. However, previous studies assessed depressive symptoms at a single time point, neglecting individual variations over time.</p>
Aims: To identify depressive symptoms trajectories through repeated measures and examine their associations with cardiovascular disease (CVD), cancer and mortality.</p>
Methods: This study included 20 634 UK Biobank participants free of CVD and cancer at baseline with two or more assessments of depressive symptoms during 2006-2016. Group-based trajectory modelling identified depressive symptoms trajectories. Incident CVD, cancer and mortality were followed up until 2021 through linked registries.</p>
Results: Six depressive symptoms trajectories were identified: no symptoms (n=6407), mild-stable (n=11 539), moderate-stable (n=2183), severe-decreasing (n=206), moderate-increasing (n=177) and severe-stable (n=122). During a median follow-up of 5.5 years, 1471 CVD cases, 1275 cancer cases and 503 deaths were documented. Compared with the no symptoms trajectory, the mild-stable, moderate-stable and severe-stable trajectories exhibited higher CVD risk, with hazard ratios (HRs) (95% CIs) of 1.19 (1.06 to 1.34), 1.32 (1.08 to 1.34) and 2.99 (1.85 to 4.84), respectively. Moderate-increasing and severe-stable trajectories were associated with higher mortality risks, with HRs (95% CIs) of 2.27 (1.04 to 4.93) and 3.26 (1.55 to 6.88), respectively. However, the severe-decreasing trajectory was not associated with higher risks of adverse outcomes. We did not find significant associations between any trajectory and cancer.</p>
Conclusions: Trajectories related to stable and increasing depressive symptoms, but not the trajectory associated with severe depressive symptoms at the initial assessment but decreasing at the follow-up, were associated with higher risks of CVD and mortality. Alleviating severe depressive symptoms at the initial onset may mitigate CVD and mortality risks.</p>
5 Authors
- Jiahao Min
- Zhi Cao
- Han Chen
- Xiaohe Wang
- Chenjie Xu
1 Application
| Application ID | Title |
|---|---|
| 79095 | Dietary patterns and lifestyle-related factors with human immunity and multimorbidity burden |
Enabling scientific discoveries that improve human health