| Title: | The Association of Urinary Sodium Excretion with Glaucoma and Related Traits in a Large United Kingdom Population |
| Journal: | Ophthalmology Glaucoma |
| Published: | 8 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38723778/ |
| DOI: | https://doi.org/10.1016/j.ogla.2024.04.010 |
Publication 12123
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
PURPOSE: Excessive dietary sodium intake has known adverse effects on intravascular fluid volume and systemic blood pressure, which may influence intraocular pressure (IOP) and glaucoma risk. This study aimed to assess the association of urinary sodium excretion, a biomarker of dietary intake, with glaucoma and related traits, and determine whether this relationship is modified by genetic susceptibility to disease.</p>
DESIGN: Cross-sectional observational and gene-environment interaction analyses in the population-based UK Biobank study.</p>
PARTICIPANTS: Up to 103 634 individuals (mean age: 57 years; 51% women) with complete urinary, ocular, and covariable data.</p>
METHODS: Urine sodium:creatinine ratio (UNa:Cr; mmol:mmol) was calculated from a midstream urine sample. Ocular parameters were measured as part of a comprehensive eye examination, and glaucoma case ascertainment was through a combination of self-report and linked national hospital records. Genetic susceptibility to glaucoma was calculated based on a glaucoma polygenic risk score comprising 2673 common genetic variants. Multivariable linear and logistic regression, adjusted for key sociodemographic, medical, anthropometric, and lifestyle factors, were used to model associations and gene-environment interactions.</p>
MAIN OUTCOME MEASURES: Corneal-compensated IOP, OCT derived macular retinal nerve fiber layer and ganglion cell-inner plexiform layer (GCIPL) thickness, and prevalent glaucoma.</p>
RESULTS: In maximally adjusted regression models, a 1 standard deviation increase in UNa:Cr was associated with higher IOP (0.14 mmHg; 95% confidence interval [CI], 0.12-0.17; P < 0.001) and greater prevalence of glaucoma (odds ratio, 1.11; 95% CI, 1.07-1.14; P < 0.001) but not macular retinal nerve fiber layer or ganglion cell-inner plexiform layer thickness. Compared with those with UNa:Cr in the lowest quintile, those in the highest quintile had significantly higher IOP (0.45 mmHg; 95% CI, 0.36-0.53, P < 0.001) and prevalence of glaucoma (odds ratio, 1.30; 95% CI, 1.17-1.45; P < 0.001). Stronger associations with glaucoma (P interaction = 0.001) were noted in participants with a higher glaucoma polygenic risk score.</p>
CONCLUSIONS: Urinary sodium excretion, a biomarker of dietary intake, may represent an important modifiable risk factor for glaucoma, especially in individuals at high underlying genetic risk. These findings warrant further investigation because they may have important clinical and public health implications.</p>
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>
157 Authors
- Kelsey V. Stuart
- Mahantesh I. Biradar
- Robert N. Luben
- Neeraj Dhaun
- Siegfried K. Wagner
- Alasdair N. Warwick
- Zihan Sun
- Kian M. Madjedi
- Louis R. Pasquale
- Janey L. Wiggs
- Jae H. Kang
- Marleen A.H. Lentjes
- Hugues Aschard
- Jihye Kim
- Paul J. Foster
- Anthony P. Khawaja
- Hugues Aschard
- Mark Chia
- Sharon Chua
- Ron Do
- Paul Foster
- Jae Kang
- Alan Kastner
- Anthony Khawaja
- Jihye Kim
- Marleen Lentjes
- Robert Luben
- Kian Madjedi
- Giovanni Montesano
- Louis Pasquale
- Kelsey Stuart
- Alasdair Warwick
- Janey Wiggs
- Naomi Allen
- Tariq Aslam
- Denize Atan
- Sarah Barman
- Jenny Barrett
- Paul Bishop
- Graeme Black
- Tasanee Braithwaite
- Roxana Carare
- Usha Chakravarthy
- Michelle Chan
- Sharon Chua
- Alexander Day
- Parul Desai
- Bal Dhillon
- Andrew Dick
- Alexander Doney
- Cathy Egan
- Sarah Ennis
- Paul Foster
- Marcus Fruttiger
- David Garway-Heath
- Jane Gibson
- Jeremy Guggenheim
- Chris Hammond
- Alison Hardcastle
- Simon Harding
- Ruth Hogg
- Pirro Hysi
- Pearse Keane
- Peng Tee Khaw
- Anthony Khawaja
- Gerassimos Lascaratos
- Thomas Littlejohns
- Andrew Lotery
- Phil Luthert
- Tom MacGillivray
- Sarah Mackie
- Bernadette McGuinness
- Gareth McKay
- Martin McKibbin
- Tony Moore
- James Morgan
- Eoin O'Sullivan
- Richard Oram
- Chris Owen
- Praveen Patel
- Euan Paterson
- Tunde Peto
- Axel Petzold
- Nikolas Pontikos
- Jugnoo Rahi
- Alicja Rudnicka
- Naveed Sattar
- Jay Self
- Panagiotis Sergouniotis
- Sobha Sivaprasad
- David Steel
- Irene Stratton
- Nicholas Strouthidis
- Cathie Sudlow
- Zihan Sun
- Robyn Tapp
- Dhanes Thomas
- Emanuele Trucco
- Adnan Tufail
- Ananth Viswanathan
- Veronique Vitart
- Mike Weedon
- Katie Williams
- Cathy Williams
- Jayne Woodside
- Max Yates
- Jennifer Yip
- Yalin Zheng
- Tin Aung
- Kathryn Burdon
- Li Chen
- Ching-Yu Cheng
- Jamie Craig
- Angela Cree
- Victor de Vries
- Sjoerd Driessen
- John Fingert
- Paul Foster
- Puya Gharahkhani
- Christopher Hammond
- Caroline Hayward
- Alex Hewitt
- Pirro Hysi
- Nomdo Jansonius
- Fridbert Jonansson
- Jost Jonas
- Michael Kass
- Anthony Khawaja
- Chiea Khor
- Caroline Klaver
- Jacyline Koh
- Andrew Lotery
- Stuart MacGregor
- David Mackey
- Paul Mitchell
- Calvin Pang
- Louis Pasquale
- Francesca Pasutto
- Norbert Pfeiffer
- Ozren Polašek
- Wishal Ramdas
- Alexander Schuster
- Ayellet Segrè
- Einer Stefansson
- Kári Stefánsson
- Gudmar Thorleifsson
- Unnur Thorsteinsdottir
- Cornelia van Duijn
- Joëlle Vergroesen
- Ananth Viswanathan
- Veronique Vitart
- Eranga Vithana
- Janey Wiggs
- James Wilson
- Robert Wojciechowski
- Tien Wong
- Terri Young
1 Application
| Application ID | Title |
|---|---|
| 36741 | Discovering the biological mechanisms underlying glaucoma and neurodegeneration by analysis of genetic and environmental determinants and associations with other systemic traits in the UK Biobank |
Enabling scientific discoveries that improve human health