| Title: | Genetic risk and incident venous thromboembolism in middle-aged and older adults following COVID-19 vaccination |
| Journal: | Journal of Thrombosis and Haemostasis |
| Published: | 5 Oct 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36111372/ |
| DOI: | https://doi.org/10.1111/jth.15879 |
| URL: | http://www.jthjournal.org/article/S1538783622183674/pdf |
| Citations: | 3 (3 in last 2 years) as of 8 Aug 2024 |
Publication 12212
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: COVID-19 vaccination has been associated with increased venous thromboembolism (VTE) risk. However, it is unknown whether genetic predisposition to VTE is associated with an increased risk of thrombosis following vaccination.</p>
METHODS: Using data from the UK Biobank, which contains in-depth genotyping and linked vaccination and health outcomes information, we generated a polygenic risk score (PRS) using 299 genetic variants. We prospectively assessed associations between PRS and incident VTE immediately after first- and the second-dose vaccination and among historical unvaccinated cohorts during the pre- and early pandemic. We estimated hazard ratios (HR) for PRS-VTE associations using Cox models.</p>
RESULTS: Of 359 310 individuals receiving one dose of a COVID-19 vaccine, 160 327 (44.6%) were males, and the mean age at the vaccination date was 69.05 (standard deviation [SD] 8.04) years. After 28- and 90-days' follow-up, 88 and 299 individuals developed VTE, respectively, equivalent to an incidence rate of 0.88 (95% confidence interval [CI] 0.70-1.08) and 0.92 (0.82-1.04) per 100 000 person-days. The PRS was significantly associated with a higher risk of VTE (HR per 1 SD increase in PRS, 1.41 (1.15-1.73) in 28 days and 1.36 (1.22-1.52) in 90 days). Similar associations were found in the historical unvaccinated cohorts.</p>
CONCLUSIONS: The strength of genetic susceptibility with post-COVID-19-vaccination VTE is similar to that seen in historical data. Additionally, the observed PRS-VTE associations were equivalent for adenovirus- and mRNA-based vaccines. These findings suggest that, at the population level, the VTE that occurred after the COVID-19 vaccination has a similar genetic etiology to the conventional VTE.</p>
6 Authors
- Junqing Xie
- Albert Prats-Uribe
- Maria Gordillo-Marañón
- Victoria Y. Strauss
- Dipender Gill
- Daniel Prieto-Alhambra
1 Application
| Application ID | Title |
|---|---|
| 65397 | The utilisation and safety of analgesics: a pharmacoepidemiologic and pharmacogenomic study |
Enabling scientific discoveries that improve human health