| Title: | Association of a Healthy Lifestyle with All-Cause, Cause-Specific Mortality and Incident Cancer among Individuals with Metabolic Syndrome: A Prospective Cohort Study in UK Biobank |
| Journal: | International Journal of Environmental Research and Public Health |
| Published: | 11 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36011568/ |
| DOI: | https://doi.org/10.3390/ijerph19169936 |
| URL: | https://www.mdpi.com/1660-4601/19/16/9936/pdf?version=1660283415 |
| Citations: | 7 (5 in last 2 years) as of 8 Aug 2024 |
Publication 12277
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Abstract
This study investigated the association between a healthy lifestyle with all-cause, cause-specific mortality, and cancer incidence among individuals with metabolic syndrome (MetS). Healthy lifestyle scores were created based on MetS management guidelines, including never/quitting smoking, moderate drinking, good sleep, healthy diet, sufficient exercise, social support, and less sedentary behaviour. Weighted healthy lifestyle scores were further constructed and classified into three groups: unfavourable (lowest quintile), intermediate (quintiles 2−4), and favourable (highest quintile) lifestyles. We included 87,342 MetS participants from the UK Biobank. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using multivariate-adjusted Cox proportional hazards regression. During a median follow-up of 12.54 years, 6739 deaths were reported; during a median follow-up of 10.69 years, 10,802 new cancer cases were documented. We found a favourable lifestyle was inversely associated with all-cause mortality (HR: 0.57; 95%CI: 0.53−0.62), cause-specific mortality from respiratory disease, cancer, digestive disease, cardiovascular disease (HR < 1; p-trend < 0.001), and overall cancer incidence (HR: 0.84; 95% CI: 0.79−0.90). Our results indicate that adherence to healthy lifestyles is associated with lower overall cancer incidence and all-cause mortality risk among MetS individuals. However, causality cannot be made due to the nature of observational studies.</p>
11 Keywords
- Biological Specimen Banks
- Cardiovascular Diseases
- Cause of Death
- Healthy Lifestyle
- Humans
- Incidence
- Metabolic Syndrome
- Neoplasms
- Prospective Studies
- Risk Factors
- United Kingdom
6 Authors
- E Wu
- Jun-Tao Ni
- Zhao-Hui Zhu
- Hong-Quan Xu
- Lin Tao
- Tian Xie
1 Application
| Application ID | Title |
|---|---|
| 78563 | Gene-Environment Interactions of complex diseases based on big data analysis |
Enabling scientific discoveries that improve human health