| Title: | Medical conditions associated with coffee consumption: Disease-trajectory and comorbidity network analyses of a prospective cohort study in UK Biobank |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 15 Jul 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35849013/ |
| DOI: | https://doi.org/10.1093/ajcn/nqac148 |
| Citations: | 11 (10 in last 2 years) as of 8 Aug 2024 |
Publication 12302
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Abstract
BACKGROUND: Habitual coffee consumption has been associated with multiple health benefits. A comprehensive analysis of disease trajectory and comorbidity networks in relation to coffee consumption is, however, currently lacking.</p>
OBJECTIVES: We aimed to comprehensively examine the health outcomes associated with habitual coffee consumption, through clarifying its disease trajectory and comorbidity networks.</p>
METHODS: Based on the UK Biobank cohort, we included 395,539 individuals with available information on coffee intake collected at recruitment between 2006 and 2010. These individuals were categorized as having low (<1 cup per day), moderate (1-3 cups), and high (≥4 cups) levels of coffee intake, and were followed through 2020 to ascertain 496 medical conditions. Cox regression was used to assess the associations between high-level coffee intake and the risk of medical conditions with a prevalence ≥0.5% in the study population, after adjusting for multiple confounders, using low-level coffee intake as the reference. Disease-trajectory and comorbidity network analyses were then applied to visualize the temporal and nontemporal relationships between the medical conditions that had an inverse association with high-level coffee intake.</p>
RESULTS: During a median follow-up of 11.8 years, 31 medical conditions were found to be associated with high-level coffee intake, among which 30 showed an inverse association (HRs ranged from 0.61 to 0.94). The inverse associations were more pronounced for women, compared with men. Disease-trajectory and comorbidity network analyses of these 30 conditions identified 4 major clusters of medical conditions, mainly in the cardiometabolic and gastrointestinal systems, among both men and women; 1 cluster of medical conditions following alcohol-related disorders, primarily among men; as well as a cluster of estrogen-related conditions among women.</p>
CONCLUSIONS: Habitual coffee consumption was associated with lower risks of many medical conditions, especially those in the cardiometabolic and gastrointestinal systems and those related to alcohol use and estrogen regulation.</p>
13 Keywords
- Biological Specimen Banks
- Caffeine
- Cardiovascular Diseases
- Coffee
- Cohort Studies
- Comorbidity
- Estrogens
- Female
- Humans
- Male
- Prospective Studies
- Risk Factors
- United Kingdom
11 Authors
- Can Hou
- Yu Zeng
- Wenwen Chen
- Xin Han
- Huazhen Yang
- Zhiye Ying
- Yao Hu
- Yajing Sun
- Yuanyuan Qu
- Fang Fang
- Huan Song
1 Application
| Application ID | Title |
|---|---|
| 54803 | Deciphering complex traits - phenotypic and genetic associations between traits in the UK Biobank Cohort |
Enabling scientific discoveries that improve human health