| Title: | Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 16 Jun 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35900194/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-21-1176 |
| Citations: | 7 (7 in last 2 years) as of 8 Aug 2024 |
Publication 12337
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Abstract
BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.</p>
METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.</p>
RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.</p>
CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer.</p>
IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.</p>
10 Keywords
- Cigarette Smoking
- Endometrial Neoplasms
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Prospective Studies
- Risk Factors
40 Authors
- Niki Dimou
- Wemimo Omiyale
- Carine Biessy
- Vivian Viallon
- Rudolf Kaaks
- Tracy A. O'Mara
- Elom K. Aglago
- Eva Ardanaz
- Manuela M. Bergmann
- Nicola P. Bondonno
- Tonje Braaten
- Sandra M. Colorado-Yohar
- Marta Crous-Bou
- Christina C. Dahm
- Renée T. Fortner
- Inger T. Gram
- Sophia Harlid
- Alicia K. Heath
- Annika Idahl
- Marina Kvaskoff
- Therese H. Nøst
- Kim Overvad
- Domenico Palli
- Aurora Perez-Cornago
- Carlotta Sacerdote
- Maria-Jose Sánchez
- Matthias B. Schulze
- Gianluca Severi
- Vittorio Simeon
- Giovanna Tagliabue
- Anne Tjønneland
- Thérèse Truong
- Rosario Tumino
- Mattias Johansson
- Elisabete Weiderpass
- Neil Murphy
- Marc J. Gunter
- Ben Lacey
- Naomi E. Allen
- Laure Dossus
1 Application
| Application ID | Title |
|---|---|
| 41115 | Investigating lifestyle factors on cancer outcomes |
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