| Title: | Ambient Air Pollutions Are Associated with Vitamin D Status |
| Journal: | International Journal of Environmental Research and Public Health |
| Published: | 27 Jun 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34198962/ |
| DOI: | https://doi.org/10.3390/ijerph18136887 |
| URL: | https://www.mdpi.com/1660-4601/18/13/6887/pdf?version=1624772002 |
| Citations: | 15 (11 in last 2 years) as of 8 Aug 2024 |
Publication 12696
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Abstract
Evidence on the effect of ambient air pollution on vitamin D is limited. This study aimed to examine the association of air pollution exposure with serum levels of 25-hydroxyvitamin D (25OHD) using UK Biobank health datasets. A total of 448,337 subjects were included in this analysis. Land Use Regression was applied to assess individual exposures to particulate matter with diameters ≤2.5 µm (PM2.5), ≤10 µm (PM10), nitrogen dioxide (NO2), and nitrogen oxides (NOx). Linear regression models evaluated the associations between air pollutants and serum vitamin D levels after adjustment of a series of confounders. All analyzed air pollutants were negatively associated with serum vitamin 25OHD levels. After adjusting for potential confounders, a 10 μg/m3 increase in concentrations of PM2.5, PM10, NOx, and NO2 was associated with -9.11 (95%CI: -13.25 to -4.97), -2.47 (95%CI: -4.51 to -0.43), -0.56 (95%CI: -0.82 to -0.30), and -1.64 (95%CI: -2.17 to -1.10) nmol/L decrease in serum vitamin 25OHD levels, respectively. Interaction analyses suggested that the effects of air pollution were more pronounced in females. In conclusion, long-term exposures to ambient PM2.5, PM10, NOx, and NO2 were associated with vitamin D status in a large UK cohort.</p>
9 Keywords
- Air Pollutants
- Air Pollution
- Environmental Exposure
- Female
- Humans
- Nitrogen Dioxide
- Particulate Matter
- Vitamin D
- Vitamins
4 Authors
- Chenlu Yang
- Dankang Li
- Yaohua Tian
- Peiyu Wang
1 Application
| Application ID | Title |
|---|---|
| 69741 | Environmental exposures, medicine use, genetic susceptibility, and the risk of cardiovascular diseases and psychiatric disorders |
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