| Title: | Intrinsic structural covariation links cerebellum subregions to the cerebral cortex |
| Journal: | Journal of Neurophysiology |
| Published: | 25 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39052236/ |
| DOI: | https://doi.org/10.1152/jn.00164.2024 |
| URL: | https://doi.org/10.1101/2024.02.16.580701 |
Publication 12780
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Abstract
The human cerebellum is increasingly recognized to be involved in non-motor and higher-order cognitive functions. Yet, its ties with the entire cerebral cortex have not been holistically studied in a whole-brain exploration with a unified analytical framework. Here, we characterized dissociable cortical-cerebellar structural covariation patterns based on regional gray matter volume (GMV) across the brain in n=38,527 UK Biobank participants. Our results invigorate previous observations in that important shares of cortical-cerebellar structural covariation are described as i) a dissociation between the higher-level cognitive system and lower-level sensorimotor system, as well as ii) an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel pattern of ipsilateral, rather than contralateral, cerebral-cerebellar associations. Furthermore, phenome-wide association assays revealed key phenotypes, including cognitive phenotypes, lifestyle, physical properties, and blood assays, associated with each decomposed covariation pattern, helping to understand their real-world implications. This systems neuroscience view paves the way for future studies to explore the implications of these structural covariations, potentially illuminating new pathways in our understanding of neurological and cognitive disorders.</p>
8 Authors
- Zilong Wang
- Jörn Diedrichsen
- Karin Saltoun
- Christopher Steele
- Sheeba Rani Arnold-Anteraper
- B.T. Thomas Yeo
- Jeremy D. Schmahmann
- Danilo Bzdok
1 Application
| Application ID | Title |
|---|---|
| 25163 | Structural genetic contributions brain function and behavior |
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