| Title: | Chronic pain in multiple sites is associated with cardiovascular dysfunction: an observational UK Biobank cohort study |
| Journal: | British Journal of Anaesthesia |
| Published: | 12 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39003202/ |
| DOI: | https://doi.org/10.1016/j.bja.2024.06.021 |
Publication 12845
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Chronic pain is associated with development of cardiovascular disease. We investigated the association between how widespread chronic pain is and the development of cardiovascular dysfunction.</p>
METHODS: We analysed data from participants enrolled in the UK Biobank study who underwent examinations at baseline, plus first follow-up and two imaging visits. Pain sites (including hip, knee, back, neck/shoulder, or 'all over the body') and pain duration were recorded at each visit. Chronic pain was defined as pain lasting for ≥3 months. Participants were categorised into six groups: no chronic pain, chronic pain in one, two, three, or four sites, or 'all over the body'. Arterial stiffness index was measured at each time point. Carotid intima-media thickness, cardiac index, and left ventricular ejection fraction (LVEF) were measured using ultrasound and heart MRI at two additional imaging visits in a subset of participants. Mixed-effect linear regression models were used for the analyses.</p>
RESULTS: The number of chronic pain sites was directly related to increased arterial stiffness index (n=159,360; β=0.06 per one site increase, 95% confidence interval 0.04 to 0.08). In 23,899 participants, lower LVEF was associated with widespread chronic pain (β=-0.17 per one site increase, 95% confidence interval -0.27 to -0.07). The number of chronic pain sites was not associated with carotid intima-media thickness (n=30,628) or cardiac index (n=23,899).</p>
CONCLUSION: A greater number of chronic pain sites is associated with increased arterial stiffness and poorer cardiac function, suggesting that widespread chronic pain is an important contributor to cardiovascular dysfunction.</p>
6 Authors
- Jing Tian
- Ziyuan Shen
- Brad A Sutherland
- Flavia Cicuttini
- Graeme Jones
- Feng Pan
1 Application
| Application ID | Title |
|---|---|
| 68213 | Impact of multisite musculoskeletal pain and its mechanism |
Enabling scientific discoveries that improve human health