| Title: | The NEMP family supports metazoan fertility and nuclear envelope stiffness |
| Journal: | Science Advances |
| Published: | 28 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32923640/ |
| DOI: | https://doi.org/10.1126/sciadv.abb4591 |
| URL: | https://advances.sciencemag.org/content/advances/6/35/eabb4591.full.pdf |
| Citations: | 13 (6 in last 2 years) as of 8 Aug 2024 |
Publication 12899
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Abstract
Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility.</p>
31 Authors
- Yonit Tsatskis
- Robyn Rosenfeld
- Joel D Pearson
- Curtis Boswell
- Yi Qu
- Kyunga Kim
- Lacramioara Fabian
- Ariz Mohammad
- Xian Wang
- Michael I Robson
- Karen Krchma
- Jun Wu
- João Gonçalves
- Didier Hodzic
- Shu Wu
- Daniel Potter
- Laurence Pelletier
- Wade H Dunham
- Anne-Claude Gingras
- Yu Sun
- Jin Meng
- Dorothea Godt
- Tim Schedl
- Brian Ciruna
- Kyunghee Choi
- John R B Perry
- Rod Bremner
- Eric C Schirmer
- Julie A Brill
- Andrea Jurisicova
- Helen McNeill
1 Application
| Application ID | Title |
|---|---|
| 9797 | Understanding the aetiology of reproductive ageing and disorders |
Enabling scientific discoveries that improve human health