| Title: | Childhood maltreatment, adulthood obesity and incident type 2 diabetes: a retrospective cohort study using UK Biobank |
| Journal: | International Journal of Obesity |
| Published: | 15 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39407013/ |
| DOI: | https://doi.org/10.1038/s41366-024-01652-x |
Publication 13220
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Abstract
BackgroundThis study aims to explore the association of childhood maltreatment with obesity and type 2 diabetes (T2D) in adulthood, and whether obesity is a mediator of the latter.MethodsIn a retrospective cohort study using UK Biobank data, participants recalled childhood maltreatment. Linear regression, logistic regression, and Cox proportional hazard models were used to investigate the associations with body mass index (BMI), obesity, and T2D, adjusted for sociodemographic factors. Decomposition analysis was used to examine the extent to which T2D excess risk was attributed to BMI.ResultsOf the 153,601 participants who completed the childhood maltreatment questions, one-third reported some form of maltreatment. Prevalence of adult obesity and incidence of T2D were higher with the number of reported childhood maltreatment types. People who reported ≥3 types of childhood maltreatment were at higher risk of obesity (OR 1.55, 95% CI 1.47-1.63) and incident T2D (HR 1.65, 95% CI 1.52-1.80). Excess T2D risk among those reporting maltreatment could be reduced by 39% if their BMI was comparable to participants who had not been maltreated, assuming causality.ConclusionsPeople who recalled maltreatment in childhood are at higher risk of T2D in adulthood, partly due to obesity.</p>
15 Authors
- Tamta Nadaraia
- Ed Whittaker
- Indira Kenyon
- Jirapitcha Boonpor
- Ziyi Zhou
- Shinya Nakada
- Ike Dhiah Rochmawati
- Carlos Celis-Morales
- Joey Ward
- Naja Hulvej Rod
- Jill P. Pell
- Helen Minnis
- Thomas Hehlmann
- Frederick K. Ho
- Daniel Mackay
1 Application
| Application ID | Title |
|---|---|
| 71392 | Investigating complex relationships between genetics, exposures, biomarkers, endophenotypes and cardiometabolic, inflammatory, immune and brain-related health outcomes |
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