| Title: | Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels |
| Journal: | Communications Biology |
| Published: | 15 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39406990/ |
| DOI: | https://doi.org/10.1038/s42003-024-06984-y |
Publication 13229
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Abstract
Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated. We examine the causal associations of general and central adiposity with 2923 plasma proteins among 3977 Chinese adults (mean BMI = 23.9 kg/m²). Genetically-predicted body mass index (BMI), body fat percentage (BF%), waist circumference (WC), and waist-to-hip ratio (WHR) are significantly (FDR < 0.05) associated with 399, 239, 436, and 283 proteins, respectively, with 80 proteins associated with all four and 275 with only one adiposity trait. WHR is associated with the most proteins (n = 90) after adjusting for other adiposity traits. These associations are largely replicated in Europeans (mean BMI = 27.4 kg/m²). Two-sample Mendelian randomisation (MR) analyses in East Asians using cis-protein quantitative trait locus (cis-pQTLs) identified in GWAS find 30/2 proteins significantly affect levels of BMI/WC, respectively, with 10 showing evidence of colocalisation, and seven (inter-alpha-trypsin inhibitor heavy chain H3, complement factor B, EGF-containing fibulin-like extracellular matrix protein 1, thioredoxin domain-containing protein 15, alpha-2-antiplasmin, fibronectin, mimecan) are replicated in separate MR using different cis-pQTLs identified in Europeans. These findings identified potential novel mechanisms and targets, to our knowledge, for improved treatment and prevention of obesity and associated diseases.</p>
19 Keywords
- Adiposity
- Adult
- Biomarkers
- Blood Proteins
- Body Mass Index
- China
- East Asian People
- Female
- Genome-Wide Association Study
- Genomics
- Humans
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Obesity, Abdominal
- Proteomics
- Quantitative Trait Loci
- Thinness
- Waist-Hip Ratio
28 Authors
- Andri Iona
- Pang Yao
- Alfred Pozarickij
- Christiana Kartsonaki
- Saredo Said
- Neil Wright
- Kuang Lin
- Iona Millwood
- Hannah Fry
- Mohsen Mazidi
- Baihan Wang
- Yiping Chen
- Huaidong Du
- Ling Yang
- Daniel Avery
- Dan Schmidt
- Dianjianyi Sun
- Pei Pei
- Jun Lv
- Canqing Yu
- Michael Hill
- Junshi Chen
- Fiona Bragg
- Derrick Bennett
- Robin Walters
- Liming Li
- Robert Clarke
- Zhengming Chen
1 Application
| Application ID | Title |
|---|---|
| 50474 | Multi-trait trans-ethnic genetic analyses |
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