| Title: | Accelerometer-derived moderate-to-vigorous physical activity and incident nonalcoholic fatty liver disease |
| Journal: | BMC Medicine |
| Published: | 18 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39289727/ |
| DOI: | https://doi.org/10.1186/s12916-024-03618-2 |
Publication 13464
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundThe liver effects of concentrated vs. more evenly distributed moderate-to-vigorous physical activity (MVPA) patterns remain unclear. We aimed to examine the association of accelerometer-measured MVPA and different MVPA patterns with liver outcomes.MethodsEighty-eight thousand six hundred fifty-six participants without prior liver diseases from UK Biobank were included. MVPA was measured by a wrist-worn accelerometer. Based on the guideline-based threshold (≥ 150 min/week), MVPA patterns were defined as inactive (< 150 min/week), active weekend warrior (WW; ≥ 150 min/week with ≥ 50% of total MVPA achieved within 1-2 days), and regularly active (≥ 150 min/week but not active WW) patterns. The primary outcome was incident nonalcoholic fatty liver disease (NAFLD).ResultsDuring a median follow-up of 6.8 years, 562 participants developed NAFLD. Overall, there was a nonlinear inverse association of total MVPA with incident NAFLD (P for nonlinearity = 0.009): the risk of NAFLD rapidly decreased with the increment of MVPA (per 100 min/week increment: HR = 0.68; 95%CI, 0.57-0.81) when MVPA < 208 min/week, while moderately declined (HR = 0.91; 95%CI, 0.84-0.99) when MVPA ≥ 208 min/week. For MVPA patterns, compared with inactive group, both active WW (HR = 0.55, 95%CI, 0.44-0.67) and active regular (HR = 0.49, 95%CI, 0.38-0.63) group were associated with a similar lower risk of NAFLD. Similar results were observed for each secondary outcome, including incident severe liver diseases, incident liver cirrhosis, and liver magnetic resonance imaging-based liver steatosis and fibrosis.ConclusionsRegardless of whether MVPA was concentrated within 1 to 2 days or spread over most days of the week, more MVPA was associated with a lower risk of incident liver outcomes, including NAFLD, liver cirrhosis, liver steatosis, and fibrosis, to MVPA more evenly distributed.</p>
11 Keywords
- Accelerometry
- Adult
- Aged
- Exercise
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
- United Kingdom
9 Authors
- Mengyi Liu
- Ziliang Ye
- Yuanyuan Zhang
- Panpan He
- Chun Zhou
- Sisi Yang
- Yanjun Zhang
- Xiaoqin Gan
- Xianhui Qin
Enabling scientific discoveries that improve human health