| Title: | Abdominal obesity and CKD: A potential mediating role of serum metabolites in the UK Biobank population |
| Journal: | Obesity Research & Clinical Practice |
| Published: | 16 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39289047/ |
| DOI: | https://doi.org/10.1016/j.orcp.2024.09.274 |
Publication 13481
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: It is generally known that although a connection between abdominal obesity and chronic kidney disease (CKD) is well-established, there is a lack of systematic research investigating the specific roles of serum metabolites, including lipid metabolites, amino acid metabolites, carbohydrate metabolites and inflammatory substances in explaining this associations.</p>
METHODS: We included 118,020 general patients with data of serum metabolites from UK Biobank. We defined abdominal obesity and CKD based on waist circumference and ICD-10 criteria. The serum metabolites were assessed by a high-throughput nuclear magnetic resonance (NMR) based metabolic biomarker profiling platform. We conducted mediation analysis by R software and used the proportion of mediation to quantify the mediation effect.</p>
RESULTS: This study demonstrated that lipid metabolites played a more important role in mediating the relationship between abdominal obesity and CKD than amino acid metabolites and carbohydrate metabolites. And Glycoprotein Acetyls (GlycA) was the strongest mediator for the correlation between abdominal obesity and CKD, accounting for 26.4 %. And In the mediation analysis stratified by sex, we found that the mediating effects of lipid metabolites were mostly higher in men than in women, while GlycA accounted for the largest proportion of the mediation association in both two groups (31.0 % for women and 19.8 % for men).</p>
CONCLUSION: Among lipid metabolites, amino acid metabolites, carbohydrate metabolites and inflammatory substances, our study showed that infammation marker GlycA was the novel and key mediator for the correlation between abdominal obesity and CKD.</p>
11 Authors
- Hanwen Ye
- Hafiz Muhammad Yasir
- Jinbo Hu
- Wenjin Luo
- Yao Qin
- Lina Mao
- Zhuo Chen
- Xiaoru Zhang
- Qifu Li
- Xiangjun Chen
- Zhihong Wang
1 Application
| Application ID | Title |
|---|---|
| 66536 | Abdominal obesity and Diabetic Kidney Disease: A Mendelian Randomization Study |
Enabling scientific discoveries that improve human health