| Title: | Methylated GCC repeat expansion in AFF3 associates with intellectual disability |
| Journal: | Nature Genetics |
| Published: | 27 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39333768/ |
| DOI: | https://doi.org/10.1038/s41588-024-01918-0 |
Publication 13568
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Abstract
We identified methylated tandem repeat expansions that resemble the FMR1 CGG repeat that causes fragile X syndrome and investigated their association with traits in the UK Biobank. AFF3 expansion carriers had a 2.4-fold reduced probability of completing secondary education and were enriched in a cohort of individuals with intellectual disability.</p>
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