| Title: | Association of triglyceride-glucose related indices with cardiovascular diseases in individuals with low handgrip strength: a prospective cohort study of UK biobank |
| Journal: | BMC Cardiovascular Disorders |
| Published: | 7 Jan 2026 |
| DOI: | https://doi.org/10.1186/s12872-025-05480-3 |
| URL: | http://dx.doi.org/10.1186/s12872-025-05480-3 |
Publication 16861
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Abstract
BackgroundLow handgrip strength (HGS) predicts cardiovascular disease (CVD) risk, potentially via insulin resistance (IR). The triglyceride-glucose (TyG) index and its combinations with adiposity measures (TyG-BMI, TyG-WC, TyG-WHtR) enhance CVD prediction, but the prognostic value in low HGS populations is unknown.MethodsThis UK Biobank prospective cohort study analyzed 18,341 participants with low HGS (mean age 59.2 years, 61.2% female). Multivariable Cox models assessed associations between TyG-related indices and incident CVD, coronary heart disease (CHD) and stroke. Subgroup and mediation analyses identified effect modifiers and pathways; sensitivity analyses validated result robustness.ResultsOver 13.4 median years, 2,666 CVD cases occurred. Per 1-SD increase, TyG, TyG-BMI, TyG-WC and TyG-WHtR were significantly associated with higher CVD incidence (adjusted HRs: 1.08, 1.13, 1.15, 1.15 respectively; all p < 0.001). TyG-related indices showed significant interaction effects for CVD/CHD across subgroups including age, disease status and medication use. Mediation analyses indicated dyslipidemia, inflammation and IR mediated the associations.ConclusionsElevated TyG-related indices independently predict increased CVD and CHD incidence in individuals with low HGS, offering value for early risk identification and the development of preventive strategies.</p>
8 Authors
- Chunfei Song
- Dachuan Guo
- Sha Chen
- Xiangzhen Ran
- Linsong Leng
- Yu Bai
- Jianmin Yang
- Zongwei Lin
1 Application
| Application ID | Title |
|---|---|
| 151350 | Acquired Risk Factors and Incidence of Metabolic Cardiovascular Disease According to age and Genetic Susceptibility |
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