| Title: | Adherence to a Planetary Health Diet and Risk of Chronic Kidney Disease: A Longitudinal Cohort Study From the UK Biobank |
| Journal: | Mayo Clinic Proceedings |
| Published: | 29 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41467870/ |
| DOI: | https://doi.org/10.1016/j.mayocp.2025.07.035 |
Publication 16951
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Abstract
OBJECTIVE: To explore the association between a Planetary Health Diet Index (PHDI) and the risk of chronic kidney disease (CKD).</p>
METHODS: Data were analyzed from 98,374 middle-aged adults from the UK Biobank cohort without CKD and were followed up from July 13, 2011, to November 8, 2021. Using at least two 24-hour dietary assessments, we calculated the PHDI score, ranging from 0 to 130 points (highest adherence) based on 14 food groups. Cases of CKD were obtained from primary care, hospital, and death records. We used multivariable Cox models to estimate hazard ratios (HRs) and their 95% confidence intervals (95% CIs) to analyze the study associations.</p>
RESULTS: During a median 9.41-year follow-up, CKD developed in 2635 (2.7%) participants. Comparing the highest with the lowest adherence quintile of the PHDI, the fully adjusted HR (95% CI) for CKD risk was 0.74 (0.65 to 0.85). Results remained robust in sensitivity analyses. The major contributors to the lower CKD risk were high consumption of vegetables (HR per 2-point increment, 0.97 [0.94 to 0.99]), fruits (0.97 [0.95 to 0.99]), and whole grains (0.97 [0.96 to 0.99]) and low consumption of starchy vegetables (0.98 [0.95 to 1.00]), poultry (0.98 [0.95 to 1.00]), and added sugars and fruit juices (0.93 [0.88 to 0.98]).</p>
CONCLUSION: In this cohort of middle-aged and older British adults, greater adherence to the PHDI was associated with a lower CKD risk. Promoting this environmentally sustainable dietary pattern may also help reduce the burden of CKD.</p>
6 Authors
- Mercedes Gómez-Cao
- Javier Maroto-Rodriguez
- Rosario Ortolá
- Adrián Carballo-Casla
- Fernando Rodriguez-Artalejo
- Mercedes Sotos-Prieto
1 Application
| Application ID | Title |
|---|---|
| 80773 | The effect of novel Healthy Lifestyle Scores in the association of frailty and chronic pain with risk of cancer and CVD, as well as all-cause and cause-specific mortality in British adults |
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