| Title: | Monocyte to high-density lipoprotein ratio and risk of incident stroke, myocardial infarction, and mortality: A large prospective cohort study |
| Journal: | Atherosclerosis |
| Published: | 29 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41478253/ |
| DOI: | https://doi.org/10.1016/j.atherosclerosis.2025.120631 |
Publication 16954
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Abstract
BACKGROUND AND AIMS: Systemic inflammation plays a significant role in cardiovascular disease (CVD). Monocyte to high-density lipoprotein (HDL) ratio (MHR) has emerged as a surrogate index of residual inflammation risk. We investigated the associations of MHR with incident CVD and mortality, and to explore the additional predictive value of combining MHR with C-reactive protein (CRP).</p>
METHODS: We included 366,705 UK Biobank participants without previous coronary heart disease, stroke, or transient ischemic attack. MHR was defined as the monocyte count divided by the HDL value. Quartiles of MHR were assessed as predictors of future CVD (myocardial infarction [MI] and stroke), cardiovascular death, and all-cause mortality after adjusting for sociodemographic, lifestyle, and clinical confounders.</p>
RESULTS: During a median follow-up of 12.7 years (IQR 11.9-13.4), 10,215 (2.8 %) developed MI, 6889 (1.9 %) cases of stroke, and 27,686 (7.5 %) died. Compared with the lowest MHR quartile, the highest MHR quartile (quartile 4) was associated with an increased risk of composite CVD (HR 1.45, 95 % CI 1.37-1.53), MI (1.59, 1.49-1.71), any stroke (1.23, 1.13-1.33); ischemic stroke (1.33, 1.21-1.46); cardiovascular mortality (1.42, 1.22-1.65), and all-cause mortality (1.11, 1.07-1.15) in the fully adjusted model. Risks of future MI, stroke, and mortality were significantly higher in participants with both elevated MHR (≥0.41) and CRP (≥2 mg/L).</p>
CONCLUSIONS: MHR is associated with future CVD and mortality irrespective of CRP levels. MHR is an easily accessible marker to detect individuals with high inflammatory risk of CVD and mortality in clinical practice.</p>
8 Authors
- Zijie Wang
- Xiao Hu
- Jianshang Wen
- Yanfang Xie
- Mengqiu Zhang
- Chuanqin Fang
- Yanghua Tian
- Qi Li
1 Application
| Application ID | Title |
|---|---|
| 100889 | Role of vascular and behavioral risk factors, genes and imaging markers in cerebrovascular disease and cognitive impairment |
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