| Title: | Associations of Long-Term Night Shift Work With Incident Irritable Bowel Syndrome: A Population-Based Cohort Study |
| Journal: | Journal of Gastroenterology and Hepatology |
| Published: | 12 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40650456/ |
| DOI: | https://doi.org/10.1111/jgh.70002 |
Publication 16983
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Abstract
BACKGROUND AND AIM: To explore the impact of long-term night shift work on the incidence of irritable bowel syndrome (IBS) and the underlying mechanism.</p>
METHODS: This cohort study included 239 760 participants who were in paid employment or self-employed from the UK Biobank. The start date refers to the date when a participant joined the cohort between 2006 and 2010, whereas the end of follow-up was December 31, 2021. In-depth lifetime employment information was used to calculate the duration and frequency of night shifts. Low-grade inflammation index (INFLA score) was calculated from five circulating inflammatory biomarkers. Cox proportional hazard models were used to estimate the relationships between long-term night shifts and IBS risk.</p>
RESULTS: An increasing trend of IBS incidence was observed from day workers to regular night shift workers. Compared to day workers, rarely/some night shift workers (HR 1.097, 95% CI 1.007-1.195) and usual/permanent night shift workers (HR 1.213, 95% CI 1.046-1.407) had a higher risk of IBS. INFLA score significantly mediated this association (mediation proportion 3.6%, p < 0.05). Workers with a longer duration (≥ 3 years) (HR 1.241, 95% CI 1.073-1.436) and a higher frequency of night shifts (> 7 shifts/month) (HR 1.248, 95% CI 1.045-1.491) also showed higher IBS risks.</p>
CONCLUSION: Night shift work, longer night shift duration, and higher night shift frequency were associated with higher risks of IBS. The potential underlying mechanism may be heightened low-grade inflammation.</p>
9 Authors
- Yuxin Yao
- Xiaojie You
- Shiyu Yang
- Yujia Xie
- Haoyu Yin
- Bingxin Shang
- Yu Jiang
- Mingyue Xue
- Jixuan Ma
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
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