| Title: | The role of sleep traits in prostate, endometrial, and epithelial ovarian cancers: An observational and Mendelian randomisation study |
| Journal: | Cancer Epidemiology |
| Published: | 17 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40680354/ |
| DOI: | https://doi.org/10.1016/j.canep.2025.102877 |
Publication 17004
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Abstract
BACKGROUND: Sleep traits may influence cancer risk; however, their associations with prostate (PCa), endometrial (ECa), and epithelial ovarian (EOCa) cancer remain unclear.</p>
METHODS: We conducted an observational analysis using the UK Biobank cohort and a two-sample Mendelian randomisation (MR) analysis to investigate the association between six sleep traits-duration, chronotype, insomnia, daytime napping, daytime sleepiness, and snoring-with PCa, ECa, and EOCa risk. Cox proportional hazards models were used for the observational analysis, while the inverse variance-weighted (IVW) method was applied in MR, with multiple sensitivity analyses. A Bonferroni correction was applied to account for multiple testing.</p>
RESULTS: Among 8608 PCa, 1079 ECa, and 680 EOCa incident diagnoses (median follow-up: 6.9 years), snoring was associated with reduced EOCa risk (HR=0.78, 95 %CI: 0.62-0.98), while daytime sleepiness was associated with increased EOCa risk (HR=1.23, 95 %CI: 1.03-1.47). However, these associations were not confirmed in MR. MR suggested higher odds of PCa (ORIVW=1.05, 95 %CI: 1.01-1.11) and aggressive PCa (ORIVW=1.10, 95 %CI: 1.02-1.19) for evening compared to morning chronotype. None of the findings survived multiple testing correction.</p>
CONCLUSION: Sleep traits were not associated with PCa, ECa, or EOCa risk; however, an evening chronotype may increase PCa risk. Further research is needed to verify this association and investigate potential underlying mechanisms.</p>
9 Authors
- Christos V. Chalitsios
- Eirini Pagkalidou
- Christos K. Papagiannopoulos
- Georgios Markozannes
- Emmanouil Bouras
- Eleanor L. Watts
- The Practical Consortium
- Rebecca C. Richmond
- Konstantinos K. Tsilidis
1 Application
| Application ID | Title |
|---|---|
| 79696 | Circulating plasma metabolites, lifestyle, adiposity, and biochemical exposures and risk of major chronic diseases and their co-occurence |
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