| Title: | Association Between Chronic Pain and Risk of Glaucoma: A Prospective Cohort Study |
| Journal: | Translational Vision Science & Technology |
| Published: | 24 Dec 2025 |
| DOI: | https://doi.org/10.1167/tvst.14.12.24 |
| URL: | http://dx.doi.org/10.1167/tvst.14.12.24 |
Publication 17041
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Abstract
Purpose
Chronic pain is a prevalent condition. Despite overlapping pathophysiological mechanisms, the association between chronic pain and glaucoma remains unclear. This study aimed to investigate their association through a prospective cohort analysis using data from the UK Biobank.</p>Methods
Chronic pain was assessed at baseline through questionnaire. The patterns analyzed included the number of chronic pain locations and different single-location chronic pain. Participants were followed up until glaucoma diagnosis, death, or censoring. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazard models, adjusted for covariates.</p>Results
Compared to individuals without chronic pain, those with chronic pain in three or more locations were at a significantly higher risk of glaucoma, with HRs of 1.20 (95% CI, 1.10-1.30; P < 0.001) for pain in three locations and 1.34 (95% CI, 1.24-1.46; P < 0.001) for pain in four or more locations. However, chronic pain in one or two locations did not show a significant association with glaucoma, and no individual pain location was independently associated with glaucoma risk.</p>Conclusions
This study highlighted the potential cumulative effect of chronic pain across multiple locations on glaucoma risk.</p>Translational Relevance
These findings highlight the potential need for further investigation into glaucoma screening in populations with chronic pain in multiple locations.</p></p>
12 Authors
- Jianqi Chen
- Yingting Zhu
- Shaofen Huang
- Zhidong Li
- Rui Xie
- Shitong Huang
- Ningfeng Li
- Hanyang Yu
- Ruiyu Luo
- Jingying Liang
- Yunxia Leng
- Yehong Zhuo
1 Application
| Application ID | Title |
|---|---|
| 95829 | Application of Artificial Intelligence for Screening of Risk Factors and Prediction of Disease Progression for Glaucoma and Myopia |
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