| Title: | Frailty, genetic susceptibility, and the risk of abdominal aortic aneurysm: Evidence from the UK Biobank cohort study |
| Journal: | Atherosclerosis |
| Published: | 23 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41468623/ |
| DOI: | https://doi.org/10.1016/j.atherosclerosis.2025.120623 |
Publication 17054
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Abstract
BACKGROUND AND AIMS: Despite the frequent co-occurrence of frailty and abdominal aortic aneurysm (AAA), it remains unclear whether frailty is a risk factor for the development of AAA. This study aims to determine the association.</p>
METHODS: The study recruited a large-scale cohort from the UK Biobank. The baseline frailty level was assessed through frailty phenotype and frailty index, categorizing participants as non-frail, pre-frail, or frail. The primary outcome was incidence of AAA during follow-up. Cox proportional hazards model was used to explore the association of frailty with AAA risk. The genetic susceptibility was assessed by polygenic risk score.</p>
RESULTS: A total of 410,606 participants were enrolled in this study. Over a median follow-up of 12.56 years, AAA developed in 692(0.3 %), 931(0.5 %), and 180(1.0 %) participants categorized as non-frail, pre-frail, and frail respectively under the frailty phenotype, while the frailty index revealed 626(0.3 %), 873(0.6 %), and 304(1.1 %) cases across corresponding frailty strata. Compared with the non-frail participants, the risk of AAA was significantly elevated in pre-frail participants (frailty phenotype: HR = 1.28, 95 %CI = 1.16-1.42; frailty index: HR = 1.43, 95 %CI = 1.28-1.59) and frail participants (frailty phenotype: HR = 1.82, 95 % CI = 1.52-2.18; frailty index: HR = 2.03, 95 %CI = 1.74-2.37). The association remained robust in further adjustment of genetic susceptibility and subgroup analysis. Using non-frail participants with low genetic susceptibility as the reference group, those frail participants with high genetic susceptibility demonstrated the greatest hazard for incident AAA, underscoring their synergistic effect on AAA.</p>
CONCLUSIONS: Frailty was longitudinally associated with a high long-term risk of AAA, suggesting frailty as a new independent risk factor for AAA.</p>
11 Authors
- Yiyang Tang
- Mukamengjiang Juaiti
- Xinyi Zhou
- Baohua Peng
- Zhenzhen Da
- Ziwei Ou
- Wenchao Lin
- Mengqiu Zhang
- Zaixin Yu
- Lihuang Zha
- Benhui Liang
1 Application
| Application ID | Title |
|---|---|
| 107175 | Investigating the association between genetics, lifestyles, environmental, and other factors in the occurrence, progression, and prognosis of aging-related cardiovascular diseases. |
Enabling scientific discoveries that improve human health