| Title: | Planetary health diet benefits brain health by decelerating biological aging |
| Journal: | Journal of Affective Disorders |
| Published: | 19 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41422973/ |
| DOI: | https://doi.org/10.1016/j.jad.2025.120975 |
Publication 17089
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Planetary Health Diet promotes well-being of both individuals and the planet; however, whether adherence to this diet benefits brain health is less known. Using data from the UK Biobank, we examined the association between the Planetary Health Diet and risk of brain disorders and if decelerated biological aging mediated this relationship. During a median follow-up of 148 months in 69,370 participants (mean (s.d.) age 55.79 (7.85) years, 54.63 % women), the highest adherence to the Planetary Health Diet (in the highest quartile of the Planetary Health Diet Index) was associated with a 12 % (hazard ratio = 0.88, 95 % confidence interval = 0.77-1.00), 13 % (0.87, 0.76-1.00), 13 % (0.87, 0.76-0.98), and 19 % (0.81, 0.67-0.97) lower risk of stroke, depression, anxiety, and multimorbidity, respectively. The association of the Planetary Health Diet with Parkinson's disease (p-value = 0.0161) and anxiety (p-value = 0.0053) showed significant nonlinearity, whereas it had a linear association with other brain disorders. Decelerated biological aging mediated 2.36-13.03 % of the relationship between the Planetary Health Diet and brain disorder risk. Our findings support the Planetary Health Diet and biological aging deceleration for the prevention and control of brain disorders.</p>
12 Keywords
- Aged
- Aging
- Anxiety
- Brain
- Diet, Healthy
- Female
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Stroke
- United Kingdom
7 Authors
- Xi Li
- Zhaoyu Wang
- Gram Lu
- Hongguang Chen
- Yi Yang
- Jue Liu
- Liyuan Tao
1 Application
| Application ID | Title |
|---|---|
| 79114 | The associations of lifestyle and socioeconomic status with respiratory outcomes: a prospective cohort study |
Enabling scientific discoveries that improve human health